Szwajgier Dominik, Baranowska-Wojcik Ewa, Borowiec Kamila
Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950, Poland.
Curr Alzheimer Res. 2018;15(6):531-543. doi: 10.2174/1567205014666171128102557.
Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.
众多作者已提供了有关酚酸及其衍生物对阿尔茨海默病（AD）有益作用的证据。在本综述中，讨论了酚酸作为乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制剂的作用，包括构效关系。此外，还介绍了酚酸对淀粉样β肽（Aβ）纤维形成的抑制作用。我们还涵盖了有关预防和治疗认知增强的体外、离体和体内研究。
