Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland.
Department of Bromatology and Nutrition Physiology, Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
Nutrients. 2022 Jul 20;14(14):2969. doi: 10.3390/nu14142969.
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcholinesterase/butyrylcholinesterase) inhibitors to patients diagnosed with the disease. However, AD prevention is possible by administering the correct inhibitors with food. The aim of this study was to examine 19 types of honey in terms of their contents of cholinesterase inhibitors. The inhibition of AChE and BChE relative to the respective honey samples was evaluated using Ellman's colorimetric method, including the "false-positive" effect. The highest potential for AChE inhibition was observed in the case of thyme honey (21.17% inhibition), while goldenrod honey showed the highest capacity for BChE inhibition (33.89%). Our study showed that honeys may provide a rich source of cholinesterase inhibitors and, in this way, play a significant role in AD.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是神经递质（乙酰胆碱）水平低、氧化应激和中枢神经系统炎症。目前唯一可用的治疗形式是给确诊患有该疾病的患者开乙酰胆碱酯酶/丁酰胆碱酯酶（AChE/BChE）抑制剂。然而，通过用食物给患者服用正确的抑制剂，可以预防 AD。本研究旨在研究 19 种蜂蜜中胆碱酯酶抑制剂的含量。使用 Ellman 比色法评估了相对于各蜂蜜样本的 AChE 和 BChE 的抑制作用，包括“假阳性”效应。百里香蜂蜜对 AChE 的抑制作用最强（抑制率为 21.17%），而一枝黄花蜂蜜对 BChE 的抑制作用最强（抑制率为 33.89%）。我们的研究表明，蜂蜜可能是胆碱酯酶抑制剂的丰富来源，并以这种方式在 AD 中发挥重要作用。
