Shoji T, Tabata T, Nishizawa Y, Kikunami K, Matsushita Y, Inoue T, Kenmotsu M, Miki T, Morii H
Inoue Hospital, Osaka, Japan.
Nephron. 1989;51(3):338-43. doi: 10.1159/000185319.
Serum fructosamine levels were investigated in patients with uremia undergoing various modes of treatment. The serum fructosamine levels correlated positively with the blood glucose levels determined a week or two earlier. The fructosamine levels were significantly affected by the protein concentration, and those corrected for protein concentrations had a closer correlation to the blood glucose levels than did the uncorrected levels. The corrected fructosamine levels were not significantly different between healthy volunteers and nondiabetic patients with uremia on conservative treatment. In an in vitro system, fructosamine concentrations were hardly affected by urea, which is known to influence the level of hemoglobin A1. These results suggest that serum fructosamine measurement can provide us with reliable information on a short-term glycemic condition, even in azotemic patients. To be more precise, the serum level of fructosamine corrected for protein concentration can be an excellent glycemic index which is not susceptible to over- or dehydration and is of high clinical value, especially in the management of diabetic patients with chronic renal failure.
对接受各种治疗方式的尿毒症患者的血清果糖胺水平进行了研究。血清果糖胺水平与一两周前测定的血糖水平呈正相关。果糖胺水平受蛋白质浓度的显著影响，校正蛋白质浓度后的果糖胺水平与血糖水平的相关性比未校正的水平更密切。健康志愿者和接受保守治疗的非糖尿病尿毒症患者校正后的果糖胺水平无显著差异。在体外系统中，果糖胺浓度几乎不受尿素的影响，而尿素已知会影响糖化血红蛋白A1的水平。这些结果表明，即使在氮质血症患者中，血清果糖胺测量也能为我们提供关于短期血糖状况的可靠信息。更确切地说，校正蛋白质浓度后的血清果糖胺水平可以是一个极好的血糖指数，不易受过度或脱水影响，具有很高的临床价值，尤其是在糖尿病合并慢性肾衰竭患者的管理中。
