Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Environ Res. 2018 Feb;161:336-344. doi: 10.1016/j.envres.2017.11.027. Epub 2017 Nov 28.
Certain phthalates are suspected to be endocrine disruptors that are adversely associated with male reproductive health. However, the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men have not been thoroughly studied.
To investigate the predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among adult Chinese males.
We measured mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-octyl phthalate (MOP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) concentrations in seminal plasma and repeated spot-urine samples from 687 men who visited a reproductive center. Mixed-effect models were used to examine the associations of sociodemographic, lifestyle and medical factors with urinary metabolite concentrations. Linear regression models were used to identify predictors of metabolite concentrations in seminal plasma and correlations between metabolite concentrations in spot urine samples and seminal plasma.
Measurements taken from spot urine samples poorly predicted same-day seminal plasma concentrations (all R<0.10). Inverse associations were observed between education level and urinary MBP and MEOHP and between household income and urinary MMP; receiving intravenous infusion therapy was associated with increased urinary MBP, MEHHP and MEOHP, use of facial cleanser/cream was associated with increased MEP, and smoking was associated with increased MEHP. The predictors of metabolite concentrations in seminal plasma differed from those in urine, except for the association of intravenous infusion therapy with MBP. BMI was associated with increased seminal plasma MBP, MEHP and MEOHP, smoking was associated with increased MEP, and contact with plastics was associated with increased MEOHP.
Phthalate metabolite concentrations in adult men varied in accordance with sociodemographic variables, lifestyle factors and intravenous therapy. Measures of metabolite levels in urine may not directly reflect the exposure status of the male reproductive system.
某些邻苯二甲酸酯类物质被怀疑是内分泌干扰物，它们与男性生殖健康呈负相关。然而，在生殖年龄段的男性中，尿液和精浆中邻苯二甲酸代谢物浓度的预测因子和相关性尚未得到充分研究。
探讨成年中国男性尿液和精浆中邻苯二甲酸代谢物浓度的预测因子和相关性。
我们测量了 687 名男性的精浆和多次随机尿液样本中的单丁基邻苯二甲酸酯（MBP）、单苄基邻苯二甲酸酯（MBzP）、单甲基邻苯二甲酸酯（MMP）、单乙基邻苯二甲酸酯（MEP）、单正辛基邻苯二甲酸酯（MOP）、单（2-乙基己基）邻苯二甲酸酯（MEHP）、单（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP）和单（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP）浓度。混合效应模型用于检验社会人口统计学、生活方式和医学因素与尿代谢物浓度的关系。线性回归模型用于确定精浆中代谢物浓度的预测因子以及随机尿样中代谢物浓度与精浆之间的相关性。
从随机尿液样本中的测量结果很难预测同日的精浆浓度（所有 R<0.10）。教育水平与尿 MBP 和 MEOHP 呈负相关，家庭收入与尿 MMP 呈负相关；静脉输液治疗与尿 MBP、MEHHP 和 MEOHP 增加有关，使用洗面奶/霜与 EEP 增加有关，吸烟与 MEHP 增加有关。精浆中代谢物浓度的预测因子与尿液中的不同，除了静脉输液治疗与 MBP 的关联。BMI 与精浆中 MBP、MEHP 和 MEOHP 增加有关，吸烟与 MEP 增加有关，接触塑料与 MEOHP 增加有关。
成年男性的邻苯二甲酸酯代谢物浓度随社会人口统计学变量、生活方式因素和静脉治疗而变化。尿液中代谢物水平的测量值可能不能直接反映男性生殖系统的暴露状况。
