论骨骼肌收缩力的起源
On the origin of the contractile force in skeletal muscle.
作者信息
Harrington W F
出版信息
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5066-70. doi: 10.1073/pnas.76.10.5066.
Abstract
Analysis of the early tension responses after abrupt step changes in the length of isometrically contracting skeletal muscle shows that the magnitude of the recovery tension (T2) and the time dependence of this process at various step displacements give a good correlation with the behavior expected for a helix-coil transition in the subfragment-2 (S-2) region of myosin. The "instantaneous" tension response (to T1) after the step change in length appears to have its origin in compliance within the coil region of S-2, which is formed through helix melting at the moment of force generation.
摘要
对等长收缩骨骼肌长度突然阶跃变化后的早期张力反应分析表明，恢复张力（T2）的大小以及该过程在不同阶跃位移下的时间依赖性，与肌球蛋白亚片段2（S-2）区域螺旋-线圈转变预期的行为具有良好的相关性。长度阶跃变化后的“瞬时”张力反应（至T1）似乎源于S-2线圈区域内的顺应性，这是在力产生瞬间通过螺旋解链形成的。
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