Department of Periodontology, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Porto Alegre, Rio Grande do Sul, Brazil.
Phytother Res. 2018 Apr;32(4):586-596. doi: 10.1002/ptr.5992. Epub 2017 Nov 29.
Copaifera ssp. produces an oil-resin that presents antiinflammatory, antitumor, antiseptic, germicidal, antifungal, and antibacterial activity. This systematic review aimed to analyze the antimicrobial action of Copaiba oil against oral pathogens, when compared to that of control substances. A search on Medline/PubMed, LILACS, SciELO, EMBASE, and SCOPUS databases were performed up to March 2017. To be included, the studies needed to perform any antimicrobial activity essay, using copaiba oil and a control substance. The antimicrobial effect of each substance, in each study, was extracted. Eleven studies were included, and several copaiba species were used. All studies showed that copaiba oil, regardless of its species, presented a bactericidal and/or bacteriostatic effect in in vitro analyzes. Only one study showed that the antimicrobial effect of the Copaifera officinalis was similar to the one found in chlorhexidine. A higher risk of bias was detected in most of the included studies. The studies demonstrated that the antimicrobial activity of copaiba oil, in most cases, is lower than chlorhexidine, which is considered the gold standard. However, there is great potential against oral bacteria. Further high quality studies are warranted in order to assess the efficacy of copaiba oil on oral pathogens.
巴西香脂树属产生的油树脂具有抗炎、抗肿瘤、防腐、杀菌、抗真菌和抗菌活性。本系统评价旨在分析巴西香脂油对口腔病原体的抗菌作用，并与对照物质进行比较。对 Medline/PubMed、LILACS、SciELO、EMBASE 和 SCOPUS 数据库进行了截至 2017 年 3 月的检索。纳入的研究需要进行任何使用巴西香脂油和对照物质的抗菌活性研究。从每项研究中提取每种物质的抗菌效果。共纳入 11 项研究，使用了几种巴西香脂树属植物。所有研究均表明，巴西香脂油，无论其种类如何，在体外分析中均表现出杀菌和/或抑菌作用。只有一项研究表明，巴西橡胶树的抗菌效果与洗必泰相似。大多数纳入的研究中都存在较高的偏倚风险。这些研究表明，在大多数情况下，巴西香脂油的抗菌活性低于被认为是金标准的洗必泰。然而，它对口腔细菌有很大的潜力。需要进一步进行高质量的研究，以评估巴西香脂油对口腔病原体的疗效。
