使用分次全身淋巴照射成功治疗（NZB/NZW）F1雌性小鼠的自身免疫性疾病。
Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.
作者信息
Slavin S
出版信息
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5274-6. doi: 10.1073/pnas.76.10.5274.
Abstract
Adult female (NZB/NZW)F1 hybrid mice with documented autoimmune glomerulonephritis resembling systemic lupus erythematosus were treated with fractionated total lymphoid irradiation (TLI), a modification of the radiotherapeutic regimen currently used for the treatment of Hodgkin disease. After TLI, proteinuria subsided in all mice that had undergone radiotherapy, and the mean survival increased from 359 days in untreated controls to 545 days. It is suggested that TLI should be further investigated as a new approach for immunoregulation of autoimmune disorders.
摘要
有记录显示患有类似系统性红斑狼疮的自身免疫性肾小球肾炎的成年雌性（NZB/NZW）F1杂交小鼠接受了分次全身淋巴照射（TLI），这是目前用于治疗霍奇金病的放射治疗方案的一种改良。TLI治疗后，所有接受放疗的小鼠蛋白尿均消退，平均生存期从未治疗对照组的359天增加到545天。有人提出，应进一步研究TLI作为一种调节自身免疫性疾病免疫的新方法。
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本文引用的文献
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The immunology and pathology of NZB mice.NZB小鼠的免疫学与病理学
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Immunofluorescence studies on thymocytotoxic antibody from New Zealand Black mice.对来自新西兰黑鼠的胸腺细胞毒性抗体的免疫荧光研究。
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The pathogenesis of autoimmunity in New Zealand black mice.新西兰黑鼠自身免疫的发病机制。
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Pathogenesis of the glomerulonephritis of NZB/W mice.NZB/W小鼠肾小球肾炎的发病机制。
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Lancet. 1968 Mar 2;1(7540):440-1. doi: 10.1016/s0140-6736(68)92778-5.
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Cyclophosphamide treatment of kidney disease in (NZB x NZW) F1 mice.环磷酰胺对（新西兰黑鼠×新西兰白鼠）F1代小鼠肾病的治疗
Lancet. 1966 Jun 11;1(7450):1280-4.
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