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相似文献

1
Reversal of nzb/nzw disease with total lymphoid irradiation.全淋巴照射逆转NZB/NZW疾病
J Exp Med. 1979 Aug 1;150(2):371-8. doi: 10.1084/jem.150.2.371.
2
Treatment of NZB/NZW mice with total lymphoid irradiation: long-lasting suppression of disease without generalized immune suppression.用全身淋巴照射法治疗NZB/NZW小鼠：疾病的长期抑制且无全身性免疫抑制。
J Immunol. 1986 May 1;136(9):3259-65.
3
Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.使用分次全身淋巴照射成功治疗（NZB/NZW）F1雌性小鼠的自身免疫性疾病。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5274-6. doi: 10.1073/pnas.76.10.5274.
4
Successful treatment of autoimmune manifestations in MRL/l and MRL/n mice using total lymphoid irradiation (TLI).使用全身淋巴照射（TLI）成功治疗MRL/l和MRL/n小鼠的自身免疫表现。
Exp Mol Pathol. 1983 Feb;38(1):33-47. doi: 10.1016/0014-4800(83)90096-5.
5
Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB x NZW)F1 mouse.IgM 同种型抗双链 DNA 抗体对（NZB×NZW）F1 小鼠狼疮疾病的抑制作用。
Arthritis Rheum. 2005 Nov;52(11):3629-38. doi: 10.1002/art.21379.
6
Therapeutic effect of early thymic irradiation in (NZB x NZW)F1 mice, associated with a selective decrease in the levels of IgG3 and gp70-anti-gp70 immune complexes.早期胸腺照射对（NZB×NZW）F1小鼠的治疗效果，与IgG3和gp70 - 抗gp70免疫复合物水平的选择性降低有关。
Cell Immunol. 1995 Apr 1;161(2):207-12. doi: 10.1006/cimm.1995.1028.
7
The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.新西兰白兔（NZW）基因对（新西兰黑兔×新西兰白兔）F1代小鼠狼疮样疾病的影响。
J Exp Med. 1987 May 1;165(5):1237-51. doi: 10.1084/jem.165.5.1237.
8
CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice.CXCR3促进IgG1自身抗体的产生，但对NZB/NZW小鼠狼疮性肾炎的发展并非必不可少。
Arthritis Rheum. 2012 Apr;64(4):1237-46. doi: 10.1002/art.33424. Epub 2011 Oct 17.
9
Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice.抑制性寡脱氧核苷酸可延缓狼疮易感的新西兰黑鼠与新西兰白鼠杂交小鼠肾小球肾炎的发病并延长其生存期。
Arthritis Rheum. 2005 Feb;52(2):651-8. doi: 10.1002/art.20810.
10
The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes.用同基因光调制脾细胞治疗（NZB/NZW）F1小鼠的自身免疫性疾病。
Scand J Immunol. 1994 May;39(5):446-52. doi: 10.1111/j.1365-3083.1994.tb03399.x.

引用本文的文献

1
Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells.辐射可减轻 NZBWF1 小鼠的系统性红斑狼疮样疾病：聚焦于 CD180 阴性细胞。
J Immunol Res. 2023 Oct 18;2023:9969079. doi: 10.1155/2023/9969079. eCollection 2023.
2
Immunomodulation of autoimmunity in MRL/lpr mice with syngeneic bone marrow transplantation (SBMT).同基因骨髓移植（SBMT）对MRL/lpr小鼠自身免疫的免疫调节作用。
Clin Exp Immunol. 1995 Apr;100(1):111-7. doi: 10.1111/j.1365-2249.1995.tb03611.x.
3
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.用抗I-A单克隆抗体治疗（新西兰黑鼠×新西兰白鼠）F1代疾病。
J Exp Med. 1983 Oct 1;158(4):1350-5. doi: 10.1084/jem.158.4.1350.
4
Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect.霍奇金病患者的自体混合淋巴细胞反应。T细胞缺陷的证据。
J Clin Invest. 1980 Jul;66(1):149-58. doi: 10.1172/JCI109828.
5
In vitro X-ray irradiation of human peripheral blood T lymphocytes enhances suppressor function.对人外周血T淋巴细胞进行体外X射线照射可增强抑制功能。
Clin Exp Immunol. 1983 Aug;53(2):444-50.
6
Prolongation of life in female NZB/NZW (F1) hybrid mice by cyclosporin A.环孢素A延长雌性NZB/NZW（F1）杂交小鼠寿命的研究
Clin Exp Immunol. 1985 Jan;59(1):1-9.
7
Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.用环孢素和（Nva2）-环孢素成功治疗（NZB×NZW）F1小鼠自身免疫：II. 肾小球肾炎的减轻
Clin Exp Immunol. 1986 May;64(2):234-42.
8
The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.新西兰白兔（NZW）基因对（新西兰黑兔×新西兰白兔）F1代小鼠狼疮样疾病的影响。
J Exp Med. 1987 May 1;165(5):1237-51. doi: 10.1084/jem.165.5.1237.
9
Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: I. Reduction of autoantibodies.用环孢素和（Nva2）-环孢素成功治疗（NZB×NZW）F1小鼠的自身免疫：I.自身抗体的减少。
Clin Exp Immunol. 1986 May;64(2):225-33.
10
New approaches to treating systemic lupus erythematosus.治疗系统性红斑狼疮的新方法。
West J Med. 1987 Aug;147(2):181-6.

本文引用的文献

1
DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice.用于检测NZB-NZW F1小鼠中抗DNA抗体的DNA结合试验。
J Immunol. 1969 Mar;102(3):788-90.
2
Therapeutic studies in NZB-W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone.对新西兰黑鼠-白鼠杂交小鼠的治疗研究。II. 硫唑嘌呤、环磷酰胺和甲基泼尼松龙的相对疗效。
Arthritis Rheum. 1972 May-Jun;15(3):247-52. doi: 10.1002/art.1780150305.
3
Therapeutic studies in NZB-W mice. I. Synergy of azathioprine, cyclophosphamide and methylprednisolone in combination.新西兰黑鼠-新西兰白鼠（NZB-W）小鼠的治疗研究。I. 硫唑嘌呤、环磷酰胺和甲基强的松龙联合使用的协同作用。
Arthritis Rheum. 1972 May-Jun;15(3):239-46. doi: 10.1002/art.1780150304.
4
The immunology and pathology of NZB mice.NZB小鼠的免疫学与病理学
Adv Immunol. 1968;9:215-66. doi: 10.1016/s0065-2776(08)60444-7.
5
Augmented incidence of neoplasia in NZB-NZW mice treated with long-term cyclophosphamide.长期接受环磷酰胺治疗的NZB-NZW小鼠肿瘤发生率增加。
J Lab Clin Med. 1973 Oct;82(4):619-33.
6
Cyclophosphamide treatment of mouse systemic lupus erythematosus.环磷酰胺治疗小鼠系统性红斑狼疮
Lab Invest. 1969 Sep;21(3):199-206.
7
Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice.成年NZB及NZB-NZW F1小鼠相对缺乏诱导耐受性的能力。
J Exp Med. 1969 Jan 1;129(1):123-39. doi: 10.1084/jem.129.1.123.
8
Immunosuppression by cyclophosphamide in NZB X NZW mice with lupus nephritis.环磷酰胺对患有狼疮性肾炎的NZB X NZW小鼠的免疫抑制作用。
Blood. 1968 Sep;32(3):436-44.
9
Pathogenesis of the glomerulonephritis of NZB/W mice.NZB/W小鼠肾小球肾炎的发病机制。
J Exp Med. 1968 Mar 1;127(3):507-22. doi: 10.1084/jem.127.3.507.
10
Cyclophosphamide treatment of renal disease in (NZB x NZW) F1 hybrid mice.环磷酰胺对（新西兰黑鼠×新西兰白鼠）F1 杂交小鼠肾病的治疗
Lancet. 1968 Mar 2;1(7540):440-1. doi: 10.1016/s0140-6736(68)92778-5.

全淋巴照射逆转NZB/NZW疾病

Reversal of nzb/nzw disease with total lymphoid irradiation.

作者信息

Kotzin B L, Strober S

出版信息

J Exp Med. 1979 Aug 1;150(2):371-8. doi: 10.1084/jem.150.2.371.

DOI:10.1084/jem.150.2.371
PMID:313431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185621/
Abstract

NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6-mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE.

摘要

NZB/NZW小鼠会自发出现类似于人类系统性红斑狼疮（SLE）的自身免疫性疾病。我们证明，与对照动物相比，全淋巴照射（TLI）可使6月龄NZB/NZW雌性小鼠中表达良好的疾病得到逆转，生存期延长，蛋白尿减少，抗DNA抗体减少。在治疗组中观察到的副作用很少。TLI还延长了患有晚期肾病动物的生存期。这些发现表明，TLI可能适用于人类SLE的治疗。