全淋巴照射逆转NZB/NZW疾病
Reversal of nzb/nzw disease with total lymphoid irradiation.
作者信息
Kotzin B L, Strober S
出版信息
J Exp Med. 1979 Aug 1;150(2):371-8. doi: 10.1084/jem.150.2.371.
Abstract
NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6-mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE.
摘要
NZB/NZW小鼠会自发出现类似于人类系统性红斑狼疮（SLE）的自身免疫性疾病。我们证明，与对照动物相比，全淋巴照射（TLI）可使6月龄NZB/NZW雌性小鼠中表达良好的疾病得到逆转，生存期延长，蛋白尿减少，抗DNA抗体减少。在治疗组中观察到的副作用很少。TLI还延长了患有晚期肾病动物的生存期。这些发现表明，TLI可能适用于人类SLE的治疗。
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本文引用的文献
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J Immunol. 1969 Mar;102(3):788-90.
2
Therapeutic studies in NZB-W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone.对新西兰黑鼠-白鼠杂交小鼠的治疗研究。II. 硫唑嘌呤、环磷酰胺和甲基泼尼松龙的相对疗效。
Arthritis Rheum. 1972 May-Jun;15(3):247-52. doi: 10.1002/art.1780150305.
3
Therapeutic studies in NZB-W mice. I. Synergy of azathioprine, cyclophosphamide and methylprednisolone in combination.新西兰黑鼠-新西兰白鼠（NZB-W）小鼠的治疗研究。I. 硫唑嘌呤、环磷酰胺和甲基强的松龙联合使用的协同作用。
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