小儿炎症性肠病中针对牛奶蛋白的血清抗体：克罗恩病与溃疡性结肠炎的比较。

Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.

作者信息

Lerner A, Rossi T M, Park B, Albini B, Lebenthal E

机构信息

Department of Pediatrics, Lady Davis Carmel Hospital, Haifa, Israel.

出版信息

Acta Paediatr Scand. 1989 Jan;78(1):81-6. doi: 10.1111/j.1651-2227.1989.tb10891.x.

DOI:10.1111/j.1651-2227.1989.tb10891.x

PMID:2919527

Abstract

Serum antibodies to five cow's milk proteins, alpha-casein, bovine serum albumin (BSA), beta-lactoglobulin A and B (BLG-a, BLG-b) and alpha-lactalbumin (ALA) were investigated in young patients with inflammatory bowel disease, 56 with Crohn's disease (CD), 24 with ulcerative colitis (UC). IgG antibodies against BSA and BLG-a and -b were higher in Crohn's disease patients as compared to those with ulcerative colitis and controls. The IgG anti-BSA were higher in the group of CD patients with higher score of disease activity. Additionally, IgA antibodies to alpha-casein were higher in CD and UC compared to control. These findings may be due to increased uptake of dietary antigens or enhanced immunological response occurring in CD patients.

摘要

对56例克罗恩病（CD）和24例溃疡性结肠炎（UC）的年轻炎症性肠病患者，研究了其针对五种牛奶蛋白（α-酪蛋白、牛血清白蛋白（BSA）、β-乳球蛋白A和B（BLG-a、BLG-b）以及α-乳白蛋白（ALA））的血清抗体。与溃疡性结肠炎患者和对照组相比，克罗恩病患者中针对BSA、BLG-a和BLG-b的IgG抗体更高。在疾病活动评分较高的CD患者组中，IgG抗BSA更高。此外，与对照组相比，CD和UC患者中针对α-酪蛋白的IgA抗体更高。这些发现可能是由于CD患者饮食抗原摄取增加或免疫反应增强所致。