鉴定两种猪红斑丹毒丝菌表面蛋白的致病作用。
Characterization of pathogenic roles of two Erysipelothrix rhusiopathiae surface proteins.
机构信息
Animal Infectious Disease Unit, National State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Animal Infectious Disease Unit, National State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan, China; Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
出版信息
Microb Pathog. 2018 Jan;114:166-168. doi: 10.1016/j.micpath.2017.11.057. Epub 2017 Nov 28.
Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. E. rhusiopathiae HP0728 and HP1472 have been reported to be down regulated in low-virulence or avirulent strains, but their pathogenic roles are not known. In this study, it was found that E. rhusiopathiae HP0728 and HP1472 were displayed on the surface of E. rhusiopathiae. Moreover, recombinant HP1472 could adhere to pig vascular endothelial cells. Recombinant HP0728 could bind host plasminogen but could not bind fibronectin. In conclusion, our work suggested that HP0728 and HP1472 are virulence factors of E. rhusiopathiae.
红斑丹毒丝菌是动物丹毒和人类类丹毒的病原体。已报道红斑丹毒丝菌 HP0728 和 HP1472 在低毒或无毒菌株中下调，但它们的致病作用尚不清楚。在这项研究中，发现红斑丹毒丝菌 HP0728 和 HP1472 显示在红斑丹毒丝菌表面。此外，重组 HP1472 可以黏附猪血管内皮细胞。重组 HP0728 可以结合宿主纤溶酶原，但不能结合纤维连接蛋白。总之，我们的工作表明 HP0728 和 HP1472 是红斑丹毒丝菌的毒力因子。
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