Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Crit Rev Oncol Hematol. 2017 Dec;120:77-85. doi: 10.1016/j.critrevonc.2017.08.011. Epub 2017 Oct 13.
Long noncoding (lnc)RNAs have emerged as essential mediators of cellular biology, differentiation and malignant transformation. LncRNAs have a broad range of possible functions at the transcriptional, posttranscriptional and protein level and their aberrant expression significantly contributes to the hallmarks of cancer cell biology. In addition, their high tissue- and cell-type specificity makes lncRNAs especially interesting as biomarkers, prognostic factors or specific therapeutic targets. Here, we review current knowledge on lncRNA expression changes during normal B-cell development, indicating essential functions in the differentiation process. In addition we address lncRNA deregulation in B-cell malignancies, the putative prognostic value of this as well as the molecular functions of multiple deregulated lncRNAs. Altogether, the discussed work indicates major roles for lncRNAs in normal and malignant B cells affecting oncogenic pathways as well as the response to common therapeutics.
长链非编码 RNA（lncRNA）已成为细胞生物学、分化和恶性转化的重要介质。lncRNA 在转录、转录后和蛋白质水平上具有广泛的潜在功能，其异常表达显著促进了癌细胞生物学的标志性特征。此外，它们高度的组织和细胞类型特异性使 lncRNA 作为生物标志物、预后因素或特定治疗靶点特别有趣。在这里，我们回顾了正常 B 细胞发育过程中 lncRNA 表达变化的最新知识，表明其在分化过程中具有重要功能。此外，我们还探讨了 B 细胞恶性肿瘤中 lncRNA 的失调、这种失调的潜在预后价值以及多个失调 lncRNA 的分子功能。总的来说，所讨论的工作表明 lncRNA 在正常和恶性 B 细胞中具有重要作用，影响致癌途径以及对常见治疗方法的反应。
