Graham Barney S, Sullivan Nancy J
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nat Immunol. 2018 Jan;19(1):20-28. doi: 10.1038/s41590-017-0007-9. Epub 2017 Dec 14.
Emerging infectious diseases will continue to threaten public health and are sustained by global commerce, travel and disruption of ecological systems. Most pandemic threats are caused by viruses from either zoonotic sources or vector-borne sources. Developing better ways to anticipate and manage the ongoing microbial challenge will be critical for achieving the United Nations Sustainable Development Goals and, conversely, each such goal will affect the ability to control infectious diseases. Here we discuss how technology can be applied effectively to better prepare for and respond to new viral diseases with a focus on new paradigms for vaccine development.
新发传染病将继续威胁公众健康,并因全球商业、旅行和生态系统破坏而持续存在。大多数大流行威胁是由人畜共患病源或媒介传播源的病毒引起的。开发更好的方法来预测和应对持续的微生物挑战对于实现联合国可持续发展目标至关重要,反之,每个这样的目标都会影响控制传染病的能力。在此,我们讨论如何有效应用技术,以更好地防范和应对新型病毒性疾病,重点是疫苗开发的新范式。