Vasudevan J A, Nair R A, Sukumaran R, Nair S G
Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
Division of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
Indian J Cancer. 2017 Jan-Mar;54(1):358-361. doi: 10.4103/ijc.IJC_89_17.
Composite tumors are defined as tumors in which there are two different intermixed histologic types. Our objective was to study the clinical and pathologic features of five cases of composite lymphoma.
Our study included five patients of composite lymphoma diagnosed over a period of 5 years. Clinical presentation, hematological parameters including peripheral smear, bone marrow aspirate, and histopathological examination of lymph node including immunohistochemistry (IHC) were studied. Treatment and follow-up details were also noted.
All the five cases were in the adult age group ranging from 44 to 72 years. All the cases were composite follicular lymphoma (FL) and mixed cellularity classical Hodgkin lymphoma (CHL). Diagnosis in all cases was suspected on morphology by identification of distinct neoplastic follicles in FL and classic Reed-Sternberg cells in CHL and confirmed by IHC.
Although rare, composite lymphomas should be kept in mind. Careful histopathological examination of lymph node with identification of distinct morphological features along with IHC helps to arrive at the definitive diagnosis.
复合肿瘤被定义为包含两种不同组织学类型相互混合的肿瘤。我们的目的是研究5例复合淋巴瘤的临床和病理特征。
我们的研究纳入了5例在5年期间诊断为复合淋巴瘤的患者。研究了临床表现、血液学参数（包括外周血涂片、骨髓穿刺）以及淋巴结的组织病理学检查（包括免疫组织化学[IHC]）。还记录了治疗和随访细节。
所有5例均为成年年龄组，年龄范围为44至72岁。所有病例均为复合滤泡性淋巴瘤（FL）和混合细胞型经典霍奇金淋巴瘤（CHL）。所有病例通过形态学检查怀疑诊断，通过识别FL中明显的肿瘤性滤泡和CHL中的经典里德-斯腾伯格细胞，并经IHC证实。
尽管复合淋巴瘤罕见，但应予以考虑。仔细的淋巴结组织病理学检查并识别独特的形态特征以及IHC有助于做出明确诊断。
