肠道-肝脏轴在慢加急性肝衰竭发病机制中的破坏
Disruption of the gut-liver axis in the pathogenesis of acute-on-chronic liver failure.
作者信息
Zhang Tao, Sun Kewei, Wang Ya, Huang Lei, Lang Ren, Jiang Wei
机构信息
The First Affiliated Hospital of Hu-Nan University of Chinese Medicine, Changsha.
Department of Microbiology and Immunologys.
出版信息
Eur J Gastroenterol Hepatol. 2018 Feb;30(2):130-135. doi: 10.1097/MEG.0000000000001026.
Abstract
Acute-on-chronic liver failure (ACLF) is characterized by organ failure mediated by acute decompensation of cirrhosis. Recent studies have highlighted the importance of the gut-liver axis (GLS) and its association with ACLF pathogenesis. In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. This knowledge may provide information useful for the design of therapeutic strategies for gut dysbiosis and its complications in ACLF.
摘要
慢加急性肝衰竭（ACLF）的特征是由肝硬化急性失代偿介导的器官功能衰竭。最近的研究强调了肠-肝轴（GLS）的重要性及其与ACLF发病机制的关联。在本综述中，我们讨论了与肠-肝轴改变相关的机制及其在ACLF发病机制中的作用，并提出了一些可能调节肠-肝轴功能障碍的治疗选择。这些知识可能为设计治疗ACLF肠道菌群失调及其并发症的策略提供有用信息。
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