Suganya Priyadharshini B S, Ummar I Syed
Department of Psychiatry, PSG Institute of Medical Science and Research, Coimbatore, Tamil Nadu, India.
Indian J Psychol Med. 2017 Sep-Oct;39(5):648-652. doi: 10.4103/IJPSYM.IJPSYM_87_17.
Objective in our study is i) To assess the prevalence and sociodemographic profile of cutaneous side effects in bipolar affective disorder patients (BPAD) on lithium. ii) To assess the course of pre-existing skin reactions, when patient is initiated on lithium therapy.
Lithium induced cutaneous side effects were assessed at baseline and monthly for 6 months followed by every 2 months over a year. Dermatologist opinion obtained to diagnose and treat for each patient who developed cutaneous side effects. Data were analyzed in percentage.
The prevalence of lithium induced cutaneous side effects in our study is 38.46%. On analyzing the individual subtype of cutaneous lesions, acneiform eruption and hairfall were most common. The cutaneous adverse reactions on lithium are more common in early adulthood than in the late adulthood and geriatric age group and among the subtypes of skin lesion acneiform eruptions are more common among males than in females. On analyzing the course of pre-existing lesions, severe alopecia developed with pre-existing systemic lupus erythematosis.
These novel finding indicate that prevalence of lithium induced cutaneous side effects continues to be high. Hence, clinician should educate the patients before initiating lithium to improve attrition rate.
我们研究的目的是：i）评估双相情感障碍患者（BPAD）在服用锂盐时皮肤副作用的患病率及社会人口统计学特征。ii）评估患者开始锂盐治疗时既往皮肤反应的病程。
在基线时以及之后的6个月内每月评估锂盐引起的皮肤副作用，随后在一年中每2个月评估一次。对于出现皮肤副作用的每位患者，获取皮肤科医生的诊断和治疗意见。数据以百分比形式进行分析。
在我们的研究中，锂盐引起的皮肤副作用患病率为38.46%。分析皮肤病变的个体亚型时，痤疮样皮疹和脱发最为常见。锂盐引起的皮肤不良反应在成年早期比成年晚期和老年年龄组更常见，在皮肤病变亚型中，痤疮样皮疹在男性中比在女性中更常见。分析既往病变的病程时，既往有系统性红斑狼疮的患者出现了严重脱发。
这些新发现表明，锂盐引起的皮肤副作用患病率仍然很高。因此，临床医生在开始使用锂盐之前应告知患者，以提高依从率。
