Okazaki Kosuke, Yamamuro Kazuhiko, Kishimoto Toshifumi
Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
Neuropsychiatr Dis Treat. 2017 Nov 21;13:2837-2840. doi: 10.2147/NDT.S148616. eCollection 2017.
Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases.
We treated a case of olanzapine-induced weight gain in a 41-year-old man with schizophrenia by switching his medication from olanzapine to asenapine.
The weight gain improved after switching the medication, from 80.3 to 75.0 kg, a weight loss of 6.6%, and there was no significant worsening of psychological symptoms or other adverse effects.
Asenapine might be effective for treating patients with schizophrenia who experience olanzapine-induced weight gain.
抗精神病药物对治疗精神分裂症有效，但非典型抗精神病药物会引起多种不良副作用，包括体重增加、高催乳素血症和锥体外系症状。此外，体重增加会增加患代谢性疾病的风险。
我们通过将一名41岁精神分裂症男性患者的药物从奥氮平换成阿立哌唑，治疗了一例奥氮平引起的体重增加病例。
换药后体重增加情况有所改善，从80.3千克降至75.0千克，体重减轻了6.6%，且心理症状或其他不良反应没有明显恶化。
阿立哌唑可能对治疗因奥氮平引起体重增加的精神分裂症患者有效。
