Havel G, Dahlenfors R, Wedell B, Mark J
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
APMIS. 1989 Feb;97(2):143-6. doi: 10.1111/j.1699-0463.1989.tb00769.x.
The chromosomes from three uterine tumours found in the same patient, two benign leiomyomas (L22 and L23) and a low-grade stroma cell sarcoma with leiomyomatous differentiation (L24), were studied by banding technique. L23 had an abnormal stemline distinguished by triosomy 12. The sarcoma showed a stemline with the same 7q-marker as L23 plus a marker del (12)(q13-24). A comparison with cytogenetically studied myomas collected from the literature showed (1) that there are at least three different recurrent, primary, gross chromosomal changes, viz. t(12;14)(q14-15;q23-24), t(1;2)(p36;p24) and del(7)(q22-31) and that there exist at least five further types of primary chromosomal deviations. The sarcoma showed aberrations identical or closely related to the recurrent structural deviations in myomas. These observations indicate a similar evolutionary pattern in benign and malignant leiomyomatous tumours.
运用显带技术对同一患者身上发现的三个子宫肿瘤的染色体进行了研究，这三个肿瘤分别是两个良性平滑肌瘤（L22和L23）以及一个具有平滑肌瘤样分化的低级别基质细胞肉瘤（L24）。L23有一条异常的干系，其特征为12号染色体三体。该肉瘤显示出一条与L23相同的7号染色体长臂标记以及一个del(12)(q13 - 24)标记的干系。与从文献中收集的经细胞遗传学研究的肌瘤进行比较发现：（1）至少存在三种不同的、反复出现的原发性染色体大改变，即t(12;14)(q14 - 15;q23 - 24)、t(1;2)(p36;p24)和del(7)(q22 - 31)，并且至少还存在另外五种原发性染色体偏差类型。该肉瘤显示出与肌瘤中反复出现的结构偏差相同或密切相关的畸变。这些观察结果表明良性和恶性平滑肌瘤样肿瘤具有相似的进化模式。
