Mark J, Havel G, Grepp C, Dahlenfors R, Wedell B
Department of Cytogenetics, Central Hospital, Skövde, Sweden.
Cancer Genet Cytogenet. 1990 Jan;44(1):1-13. doi: 10.1016/0165-4608(90)90192-d.
Chromosomal observations by banding technique in 18 short-term cultured human uterine leiomyomas are reported. Half of the tumors had a primary or secondary abnormal stemline. They were usually characterized only by structural changes, in particular reciprocal translocations or insertions. Reviewing already published cases together with the new material confirmed that the aberrations in abnormal stemlines predominantly affected chromosomes 1, 2, 6, 7, 12, 14, and X. In these chromosomes the regions 1p36, 2p24, 6p12-21, 7q21-31, 12q13-15, 14q22-24, and the short arm of the X chromosome were preferentially affected. As in two other thoroughly studied human benign tumors, the pleomorphic adenoma and the meningioma, the very specific but sometimes complex chromosomal aberrations in leiomyomas could well be events of primary evolutionary importance. Likewise, in cases with a normal stemline, it is possible that comparable changes in the corresponding specific chromosomal regions have occurred at a submicroscopic level. Ascertaining this possibility, as well as the role of the aberrations with regard to the benign nature of the tumors, must be the focus of future analysis using molecular techniques.
本文报道了采用显带技术对18例短期培养的人子宫平滑肌瘤进行的染色体观察。半数肿瘤有原发性或继发性异常干系。它们通常仅以结构改变为特征，特别是相互易位或插入。将已发表的病例与新材料一起回顾证实，异常干系中的畸变主要影响染色体1、2、6、7、12、14和X。在这些染色体中，1p36、2p24、6p12 - 21、7q21 - 31、12q13 - 15、14q22 - 24区域以及X染色体短臂优先受到影响。与另外两种经过充分研究的人类良性肿瘤，即多形性腺瘤和脑膜瘤一样，平滑肌瘤中非常特异但有时复杂的染色体畸变很可能是具有主要进化重要性的事件。同样，在干系正常的病例中，相应特定染色体区域可能在亚显微镜水平发生了类似的变化。确定这种可能性以及畸变对于肿瘤良性性质的作用，必须是未来使用分子技术进行分析的重点。
