Havel G, Wedell B, Dahlenfors R, Mark J
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(1):77-9. doi: 10.1007/BF02899067.
The chromosomes from two human uterine lipoleiomyomas, L25 and L26, from the same patient, were studied by a banding technique applied to preparations from short-term cultures. Both tumors displayed the same pseudodiploid stemline characterized by the reciprocal translocation t (5; 12) (q12; q24). These observations coincide with the previous finding that the largest subgroup of typical leiomyomas with an abnormal stemline are characterized by a long-arm change of one chromosome No. 12. The combined results support the previously advanced hypothesis that different histologic subtypes of uterine leiomyomas are derived from a common totipotential stem cell. This interpretation also fits with a proposed theory about the derivation of malignant leiomyomatous uterine neoplasms.
