• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

光萼党参富含咖啡酰奎宁酸的提取物通过调节载脂蛋白E基因敲除小鼠的过氧化物酶体增殖物激活受体和脂联素改善非酒精性脂肪肝

Caffeoylquinic Acid-Rich Extract of F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPAR and Adiponectin in ApoE KO Mice.

作者信息

Lee Yong-Jik, Jang Yoo-Na, Han Yoon-Mi, Kim Hyun-Min, Jeong Jong-Min, Son Min Jeoung, Jin Chang Bae, Kim Hyoung Ja, Seo Hong Seog

机构信息

Cardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea.

Department of Medical Science, Korea University College of Medicine (BK21 Plus KUMS Graduate Program), Main Building 6F Room 655, 73 Inchon-ro (Anam-dong 5-ga), Seongbuk-gu, Seoul 136-705, Republic of Korea.

出版信息

PPAR Res. 2017;2017:3912567. doi: 10.1155/2017/3912567. Epub 2017 Oct 23.

DOI:10.1155/2017/3912567
PMID:29201040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5672637/
Abstract

is well known for its therapeutic properties. This study was performed to investigate the effects of on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with . Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor , 5' adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPAR coactivator 1-alpha in liver tissues increased in the groups treated with . Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor , and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon . Triglyceride concentration in the liver was lower in mice treated with than in control mice. Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon treatment; this effect was suppressed in the presence of the PPAR antagonist, GSK0660. Our findings suggest that extracts may ameliorate NAFLD through regulation of PPAR, adiponectin, and the related subgenes.

摘要

以其治疗特性而闻名。本研究旨在通过测定血清、肝脏和脂肪组织中与脂质代谢和炎症相关的生物标志物水平，研究其对动脉粥样硬化状态下非酒精性脂肪性肝病（NAFLD）的影响。所有接受治疗的组中，体重、腹部脂肪组织重量和血清甘油三酯水平均下降。接受治疗的组中，血清脂联素浓度以及肝脏组织中过氧化物酶体增殖物激活受体、5' 腺苷单磷酸激活蛋白激酶、乙酰辅酶A羧化酶、超氧化物歧化酶和PPAR共激活因子1-α的蛋白水平均升高。相反，经治疗后，ATP柠檬酸裂解酶、脂肪酸合酶、肿瘤坏死因子和3-羟基-3-甲基戊二酰辅酶A还原酶的蛋白水平以及白细胞介素6和活性氧的浓度均下降。接受治疗的小鼠肝脏中的甘油三酯浓度低于对照小鼠。经治疗后，HepG2和3T3-L1细胞中的脂质积累减少；在PPAR拮抗剂GSK0660存在的情况下，这种作用受到抑制。我们的研究结果表明，提取物可能通过调节PPAR、脂联素及相关亚基因来改善NAFLD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/c1221f6c3ffa/PPAR2017-3912567.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/777e188c4172/PPAR2017-3912567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/a63351f604ef/PPAR2017-3912567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/1e75f51ec030/PPAR2017-3912567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/86f9b4754930/PPAR2017-3912567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/5936cc54316b/PPAR2017-3912567.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/17964ea0b65e/PPAR2017-3912567.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/49092005b29a/PPAR2017-3912567.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/bc6160d8f58d/PPAR2017-3912567.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/26c721ad39b7/PPAR2017-3912567.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/c1221f6c3ffa/PPAR2017-3912567.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/777e188c4172/PPAR2017-3912567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/a63351f604ef/PPAR2017-3912567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/1e75f51ec030/PPAR2017-3912567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/86f9b4754930/PPAR2017-3912567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/5936cc54316b/PPAR2017-3912567.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/17964ea0b65e/PPAR2017-3912567.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/49092005b29a/PPAR2017-3912567.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/bc6160d8f58d/PPAR2017-3912567.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/26c721ad39b7/PPAR2017-3912567.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/405d/5672637/c1221f6c3ffa/PPAR2017-3912567.010.jpg

相似文献

1
Caffeoylquinic Acid-Rich Extract of F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPAR and Adiponectin in ApoE KO Mice.光萼党参富含咖啡酰奎宁酸的提取物通过调节载脂蛋白E基因敲除小鼠的过氧化物酶体增殖物激活受体和脂联素改善非酒精性脂肪肝
PPAR Res. 2017;2017:3912567. doi: 10.1155/2017/3912567. Epub 2017 Oct 23.
2
Corrigendum to "Caffeoylquinic Acid-Rich Extract of F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPAR and Adiponectin in ApoE KO Mice".《“F. Schmidt富含咖啡酰奎尼酸提取物通过调节ApoE基因敲除小鼠的PPAR和脂联素来改善非酒精性脂肪肝”的勘误》
PPAR Res. 2019 Oct 23;2019:5317126. doi: 10.1155/2019/5317126. eCollection 2019.
3
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR Regulation in Hyperlipidemic and Hypertensive Conditions.在高脂血症和高血压情况下，非马沙坦通过调节过氧化物酶体增殖物激活受体（PPAR）改善非酒精性脂肪性肝病。
PPAR Res. 2017;2017:8048720. doi: 10.1155/2017/8048720. Epub 2017 Mar 13.
4
Extract, Including Caffeoylquinic Acids as the Main Constituents, Induces PPAR β/δ-Dependent Muscle-Type Change and Myogenesis in Apolipoprotein E Knockout Mice.提取物，包括绿原酸等主要成分，可诱导载脂蛋白 E 敲除小鼠的 PPARβ/δ 依赖性肌肉类型转变和肌发生。
J Med Food. 2024 Jun;27(6):521-532. doi: 10.1089/jmf.2024.k.0027. Epub 2024 Apr 23.
5
Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPAR-AMPK Pathway.含有咖啡酰奎宁化合物的提取物通过TRPV4-PPAR-AMPK途径保护人角质形成细胞。
Evid Based Complement Alternat Med. 2018 Dec 9;2018:9616574. doi: 10.1155/2018/9616574. eCollection 2018.
6
F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase.F.施密特提取物调节HMG-CoA还原酶和脂肪酸合酶的活性。
Plants (Basel). 2021 Oct 25;10(11):2287. doi: 10.3390/plants10112287.
7
Free radical biology for medicine: learning from nonalcoholic fatty liver disease.医学中的自由基生物学：从非酒精性脂肪性肝病中学习。
Free Radic Biol Med. 2013 Dec;65:952-968. doi: 10.1016/j.freeradbiomed.2013.08.174. Epub 2013 Aug 29.
8
Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.虾青素和安卡黄素作为天然 AMPK 激活剂，具有 PPARα 激动剂活性，可下调高脂饮食喂养的 C57BL/6 小鼠的非酒精性脂肪性肝炎。
Food Chem Toxicol. 2014 Feb;64:94-103. doi: 10.1016/j.fct.2013.11.015. Epub 2013 Nov 22.
9
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.n-3 多不饱和脂肪酸治疗酒精性肝病：批判性评价。
Crit Rev Food Sci Nutr. 2019;59(sup1):S116-S129. doi: 10.1080/10408398.2018.1544542. Epub 2018 Dec 22.
10
LB100 ameliorates nonalcoholic fatty liver disease the AMPK/Sirt1 pathway.LB100 通过 AMPK/Sirt1 通路改善非酒精性脂肪性肝病。
World J Gastroenterol. 2019 Dec 7;25(45):6607-6618. doi: 10.3748/wjg.v25.i45.6607.

引用本文的文献

1
Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?阿魏酸苯乙酯：一种有潜力的癌症治疗药物？
Curr Med Chem. 2024;31(41):6760-6774. doi: 10.2174/0109298673252993230921073502.
2
Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products.咖啡副产物中绿原酸和异绿原酸的风险评估。
Molecules. 2023 Jul 20;28(14):5540. doi: 10.3390/molecules28145540.
3
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors.

本文引用的文献

1
Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease.Toll样受体7影响非酒精性脂肪性肝病的发病机制。
Sci Rep. 2016 Jun 9;6:27849. doi: 10.1038/srep27849.
2
Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase α Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease.大豆胚通过增强脂联素介导的AMP活化蛋白激酶α通路对高脂高胆固醇饮食诱导的非酒精性脂肪性肝病的肝保护作用
J Med Food. 2016 Jun;19(6):549-59. doi: 10.1089/jmf.2015.3604.
3
Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.
刺激 Alpha-1-肾上腺素能受体通过激活糖酵解和抑制白内障诱导因素来改善肥胖诱导的白内障。
Endocrinol Metab (Seoul). 2022 Apr;37(2):221-232. doi: 10.3803/EnM.2021.1237. Epub 2022 Mar 23.
4
Evaluation of Subchronic Toxicity and Genotoxicity of Ethanolic Extract of Leaves and Stems.叶和茎乙醇提取物的亚慢性毒性和遗传毒性评价
Evid Based Complement Alternat Med. 2021 Dec 30;2021:1018101. doi: 10.1155/2021/1018101. eCollection 2021.
5
F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase.F.施密特提取物调节HMG-CoA还原酶和脂肪酸合酶的活性。
Plants (Basel). 2021 Oct 25;10(11):2287. doi: 10.3390/plants10112287.
6
3,5-Dicaffeoylquinic Acid Lowers 3T3-L1 Mitotic Clonal Expansion and Adipocyte Differentiation by Enhancing Heme Oxygenase-1 Expression.3,5-二咖啡酰奎宁酸通过增强血红素加氧酶-1 的表达来降低 3T3-L1 的有丝分裂克隆扩张和脂肪细胞分化。
Molecules. 2021 Aug 19;26(16):5027. doi: 10.3390/molecules26165027.
7
(L.) Less. Tea Ameliorates Hyperglycemia, Dyslipidemia, and Obesity in High Fat Diet-Fed Mice.（L.）莱斯。茶可改善高脂饮食喂养小鼠的高血糖、血脂异常和肥胖。
Evid Based Complement Alternat Med. 2020 Jun 3;2020:8746137. doi: 10.1155/2020/8746137. eCollection 2020.
8
The vital role of ATP citrate lyase in chronic diseases.三磷酸柠檬酸裂解酶在慢性疾病中的重要作用。
J Mol Med (Berl). 2020 Jan;98(1):71-95. doi: 10.1007/s00109-019-01863-0. Epub 2019 Dec 19.
9
Corrigendum to "Caffeoylquinic Acid-Rich Extract of F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPAR and Adiponectin in ApoE KO Mice".《“F. Schmidt富含咖啡酰奎尼酸提取物通过调节ApoE基因敲除小鼠的PPAR和脂联素来改善非酒精性脂肪肝”的勘误》
PPAR Res. 2019 Oct 23;2019:5317126. doi: 10.1155/2019/5317126. eCollection 2019.
10
6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPAR in HUVECs, HEK293, and Differentiated 3T3-L1 Cells.6-姜酚通过过氧化物酶体增殖物激活受体（PPAR）使与高血压相关的生物标志物在人脐静脉内皮细胞（HUVECs）、人胚肾293细胞（HEK293）和分化的3T3-L1细胞中的表达正常化。
PPAR Res. 2018 Dec 16;2018:6485064. doi: 10.1155/2018/6485064. eCollection 2018.
高脂血症通过氧化应激、炎症和神经元凋亡加重大脑中动脉闭塞/再灌注大鼠的脑损伤。
Exp Brain Res. 2015 Oct;233(10):2753-65. doi: 10.1007/s00221-015-4269-x. Epub 2015 Aug 4.
4
The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm.5'-腺苷酸激活蛋白激酶（AMPK）参与冷冻保存鸡精子中抗氧化防御能力的增强。
PLoS One. 2015 Jul 29;10(7):e0134420. doi: 10.1371/journal.pone.0134420. eCollection 2015.
5
Association between nonalcoholic fatty liver disease and carotid atherosclerosis: a meta-analysis.非酒精性脂肪性肝病与颈动脉粥样硬化之间的关联：一项荟萃分析。
Int J Clin Exp Med. 2015 May 15;8(5):7673-8. eCollection 2015.
6
Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells.琥珀酸通过激活肝星状细胞中的GPR91诱导α-平滑肌肌动蛋白生成。
Biochem Biophys Res Commun. 2015 Aug 7;463(4):853-8. doi: 10.1016/j.bbrc.2015.06.023. Epub 2015 Jun 5.
7
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.AICAR诱导的AMPK激活抑制肝脏中的TSH/SREBP-2/HMGCR通路。
PLoS One. 2015 May 1;10(5):e0124951. doi: 10.1371/journal.pone.0124951. eCollection 2015.
8
AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells.AMP 激酶通路参与肿瘤坏死因子 α 诱导的人肝癌细胞脂质积累。
Life Sci. 2015 Jun 15;131:23-9. doi: 10.1016/j.lfs.2015.03.003. Epub 2015 Mar 25.
9
AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid.AMP 激活的蛋白激酶对于α-亚麻酸的抗脂肪生成作用是必需的。
Nutr Metab (Lond). 2015 Mar 8;12:10. doi: 10.1186/s12986-015-0006-5. eCollection 2015.
10
5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription.5-咖啡酰奎尼酸通过调节PPARα和LXRα转录来减轻大鼠饮食诱导的肥胖。
J Sci Food Agric. 2015 Jul;95(9):1903-10. doi: 10.1002/jsfa.6896. Epub 2014 Oct 1.