Sreng Bun, Kimcheng Hok, Sovann L Y, Huot Eng
Department of Communicable Disease Control, Ministry of Health, Phnom Penh, Cambodia.
National Blood Transfusion Centre, Phnom Penh, Cambodia.
Euroasian J Hepatogastroenterol. 2015 Jan-Jun;5(1):30-33. doi: 10.5005/jp-journals-10018-1125. Epub 2015 Jan 6.
In Cambodia, the true burden of viral hepatitis has not been revealed, but many surveys were carried out focusing on specific population or on small scales. Different markers of viral hepatitis were found between 27 and 97% in children and almost 100% in adults. Viral hepatitis B in children was 3.5% in 2006 and dropped in 2011; and in adults, it ranged from 4.5 to 10.8%. Viral hepatitis C was between 0.87 and 14.7%. No data are available for hepatitis D in the country. Viral hepatitis E (anti-HEV IgG) went from 7.2 to 12.7%. The complications due to viral hepatitis including chronic liver diseases and hepatocellular carcinoma were reported in the health information system. Around 79% of the patients with high transaminase had at least one viral marker and about 45% of the adults with chronic hepatitis and liver cirrhosis were positive for Hepatitis B surface antigen (HBsAg). Hepatocellular carcinoma accounted for 19.1% of all reported cancer cases. Hepatitis B surface antigen was found in between 55 and 90% in adults with hepatocellular carcinoma and anti-HCV in one-fourth. The only intervention implemented in Cambodia is vaccination against viral hepatitis B (HepB vaccine).
Sreng B, Kimcheng HOK, Sovann LY, Huot ENG. Epidemiology of Viral Hepatitis and Liver Diseases in Cambodia. Euroasian J Hepato-Gastroenterol 2015;5(1):30-33.
在柬埔寨，病毒性肝炎的真实负担尚未明确，但已开展了许多针对特定人群或小规模人群的调查。儿童中病毒性肝炎的不同标志物检出率在27%至97%之间，成人中几乎达100%。2006年儿童中的乙型病毒性肝炎感染率为3.5%，2011年有所下降；成人中的感染率在4.5%至10.8%之间。丙型病毒性肝炎感染率在0.87%至14.7%之间。该国尚无丁型肝炎的数据。戊型病毒性肝炎（抗HEV IgG）感染率从7.2%升至12.7%。卫生信息系统报告了病毒性肝炎导致的并发症，包括慢性肝病和肝细胞癌。约79%转氨酶升高的患者至少有一种病毒标志物呈阳性，约45%患有慢性肝炎和肝硬化的成人乙肝表面抗原（HBsAg）呈阳性。肝细胞癌占所有报告癌症病例的19.1%。在患有肝细胞癌的成人中，55%至90%的人乙肝表面抗原呈阳性，四分之一的人抗丙肝病毒呈阳性。柬埔寨实施的唯一干预措施是针对乙型病毒性肝炎的疫苗接种（乙肝疫苗）。
Sreng B, Kimcheng HOK, Sovann LY, Huot ENG.柬埔寨病毒性肝炎和肝病的流行病学。《欧亚肝脏胃肠病学杂志》2015年；5(1):30 - 33。
