Epidemiology and Public Health Unit, Pasteur Institute in Cambodia, 5, Boulevard Monivong, BP 983, Phnom Penh, Cambodia,
AIDS Behav. 2014 Mar;18(3):495-504. doi: 10.1007/s10461-013-0486-0.
In 2009, we conducted a case-control study to explore the routes of HCV transmission in people living with HIV/AIDS (PLHIV) in Cambodia. Cases were HCV/HIV co-infected patients (who tested RT-PCR positive for HCV-RNA or had confirmed presence of HCV antibodies) (n = 44). Controls were HIV mono-infected patients, with no HCV antibodies (n = 160). They were recruited among the PLHIV presenting at one national reference centre of HIV/AIDS. Multivariate analysis showed that factors associated with the co-infection were the age older than 50 years (OR 5.4, 95 % confidence interval (CI) 1.5-19.6), the exposure to multiple parenteral infusions before the year 2000 (OR 3.4, 95 % CI 1.5-7.6), to surgery (OR 2.6, 95 % CI 1.2-5.7) and to fibroscopy (OR 2.4, 95 % CI 1.0-5.7). These results show the need to implement HCV screening in PLHIV, to support the implementation of national infection control guidelines, and to reinforce public awareness on the risks linked to parenteral medications.
2009 年，我们进行了一项病例对照研究，以探索柬埔寨 HIV 感染者/艾滋病患者（PLHIV）中 HCV 的传播途径。病例为 HCV/HIV 合并感染患者（HCV-RNA 经 RT-PCR 检测阳性或 HCV 抗体确证阳性）（n=44）。对照组为 HIV 单感染患者，无 HCV 抗体（n=160）。他们是在一个国家 HIV/AIDS 参考中心就诊的 PLHIV 中招募的。多因素分析显示，与合并感染相关的因素是年龄大于 50 岁（OR 5.4，95%置信区间[CI]1.5-19.6）、2000 年前多次接受静脉注射（OR 3.4，95%CI 1.5-7.6）、手术（OR 2.6，95%CI 1.2-5.7）和纤维内镜检查（OR 2.4，95%CI 1.0-5.7）。这些结果表明，需要对 PLHIV 进行 HCV 筛查，支持国家感染控制指南的实施，并加强公众对与静脉用药相关风险的认识。
