M Hussain Muhammad, Al Mahtab Mamun, Islam Shahidul, Ahmed Nooruddin, Rahman Salimur, Khan Mobin
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Department of Oncology Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Euroasian J Hepatogastroenterol. 2017 Jan-Jun;7(1):111-112. doi: 10.5005/jp-journals-10018-1228. Epub 2017 May 5.
Hepatitis B virus (HBV) infection is an established cause of hepatocellular carcinoma (HCC) and is associated with poor prognosis. High HBV deoxyribonucleic acid (DNA) load has been identified in HCC and hepatitis B surface antigen-positive patients.
This study was done in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from January 2006 to December 2007. Thirty patients with HBV infection-related HCC were enrolled. Another 30 patients with HBV-related liver diseases without HCC were analyzed as controls.
The HCC patients had a high viral load (>10 copies/mL), while all of the controls had low (<10 copies/mL) viral load.
It seems that patients with HCC bear high HBV DNA loads in Bangladesh, but the causes underlying this remain to be resolved. Hussain MM, Al Mahtab M, Islam S, Ahmed N, Rahman S, Khan M. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepato-Gastroenterol 2017;7(1):111-112.
乙型肝炎病毒（HBV）感染是肝细胞癌（HCC）的既定病因，且与预后不良相关。在肝癌患者和乙肝表面抗原阳性患者中已检测到高乙肝脱氧核糖核酸（DNA）载量。
本研究于2006年1月至2007年12月在孟加拉国达卡的班加班杜·谢赫·穆吉布医科大学肝病科进行。纳入30例HBV感染相关肝癌患者。另外30例无肝癌的HBV相关肝病患者作为对照进行分析。
肝癌患者病毒载量高（>10拷贝/mL），而所有对照病毒载量低（<10拷贝/mL）。
在孟加拉国，肝癌患者似乎携带高HBV DNA载量，但其潜在原因仍有待解决。侯赛因·MM、阿尔·马赫塔布·M、伊斯兰·S、艾哈迈德·N、拉赫曼·S、汗·M。乙型肝炎病毒脱氧核糖核酸载量与肝细胞癌的关系。《欧亚肝脏胃肠病学杂志》2017；7（1）：111 - 112。
