精神分裂症患者血浆磷脂中的必需脂肪酸

Essential fatty acids in plasma phospholipids in schizophrenics.

作者信息

Horrobin D F, Manku M S, Morse-Fisher N, Vaddadi K S, Courtney P, Glen A I, Glen E, Spellman M, Bates C

机构信息

Efamol Research Institute, Kentville, Nova Scotia, Canada.

出版信息

Biol Psychiatry. 1989 Mar 1;25(5):562-8. doi: 10.1016/0006-3223(89)90216-3.

DOI:10.1016/0006-3223(89)90216-3

PMID:2920191

Abstract

Blood samples were taken from schizophrenics and control patients in three different centers. The phospholipids were extracted from plasma and their fatty acid composition analyzed. Similar and consistent differences between schizophrenics and controls were observed at all three centers. The n-6 essential fatty acid levels were significantly reduced, whereas n-3 essential fatty acids were elevated.

摘要

在三个不同的中心采集了精神分裂症患者和对照患者的血样。从血浆中提取磷脂并分析其脂肪酸组成。在所有三个中心都观察到精神分裂症患者和对照患者之间存在相似且一致的差异。n-6必需脂肪酸水平显著降低，而n-3必需脂肪酸水平升高。