Division of Neurology, Department of Internal Medicine, Faculty of Medicine, University of Manitoba Winnipeg, MB, Canada.
Front Psychiatry. 2012 Dec 28;3:108. doi: 10.3389/fpsyt.2012.00108. eCollection 2012.
what final common pathway can induce a convincing sense of the reality of the hallucinations in this disease? The observation that artificial stimulation of an intermediate order of neurons of a normal nervous system induces hallucinations indicates that the lateral entry of activity (not resulting from canonical synaptic transmission) at intermediate neuronal orders may provide a mechanism for hallucinations. Meaningful hallucinations can be de-constructed into an organized temporal sequence of internal sensations of associatively learned items that occur in the absence of any external stimuli. We hypothesize that these hallucinations are autonomously generated by the re-activation of pathological non-specific functional LINKs formed between the postsynaptic membranes at certain neuronal orders and are examined as a final common mechanism capable of explaining most of the features of the disease. Reversible and stabilizable hemi-fusion between simultaneously activated adjacent postsynaptic membranes is viewed as one of the normal mechanisms for functional LINK formation and is dependent on lipid membrane composition. Methods of removing the proteins that may traverse the non-specifically hemi-fused membrane segments and attempts to replace the phospholipid side chains to convert the membrane composition to a near-normal state may offer therapeutic opportunities.
究竟是什么最终共同通路能够在这种疾病中引起对幻觉真实性的令人信服的感觉？人工刺激正常神经系统中中间神经元序的活动会引起幻觉，这一观察结果表明，中间神经元序的活动的侧向进入（不是源自规范的突触传递）可能为幻觉提供了一种机制。有意义的幻觉可以被分解为在没有任何外部刺激的情况下，由联想学习项目的内部感觉组成的有组织的时间序列。我们假设这些幻觉是由特定神经元序的突触后膜之间形成的病理性非特异性功能 LINK 的病理性再激活自主产生的，并将其作为能够解释该疾病大部分特征的最终共同机制进行研究。同时激活的相邻突触后膜之间可逆且稳定的半融合被视为形成功能 LINK 的正常机制之一，并且依赖于脂质膜组成。去除可能穿过非特异性半融合膜段的蛋白质的方法以及尝试用替换磷脂侧链的方法将膜组成转化为接近正常状态的方法可能提供治疗机会。
