世贸中心救援人员的创伤暴露、创伤后应激障碍和认知功能
Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders.
作者信息
Clouston Sean, Pietrzak Robert H, Kotov Roman, Richards Marcus, Spiro Avron, Scott Stacey, Deri Yael, Mukherjee Soumyadeep, Stewart Candace, Bromet Evelyn, Luft Benjamin J
机构信息
Stony Brook University, Stony Brook, NY, USA.
Yale University, New Haven, CT, USA.
出版信息
Alzheimers Dement (N Y). 2017 Oct 19;3(4):593-602. doi: 10.1016/j.trci.2017.09.001. eCollection 2017 Nov.
INTRODUCTION
This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data.
METHODS
A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms.
RESULTS
Approximately 14.8% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with lower cognition.
DISCUSSION
Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.
引言
本研究探讨了与世界贸易中心（WTC）相关的暴露因素和创伤后应激障碍（PTSD）是否与认知功能相关，以及WTC应急响应人员的认知与标准数据是否存在差异。
方法
对1193名无中风病史或与WTC相关头部损伤史的WTC应急响应人员进行前瞻性队列研究，并采用计算机辅助神经心理测验。数据与自2002年以来前瞻性收集的信息相关联。将样本平均值与已发表的标准进行比较。
结果
约14.8%的抽样应急响应人员存在认知功能障碍。与标准数据相比，WTC应急响应人员的认知功能较差。PTSD症状严重程度和在现场工作超过5周与较低的认知水平相关。
讨论
该样本的结果突出了WTC应急响应人员可能承受着认知功能障碍增加的负担，并将认知功能下降与身体暴露和PTSD联系起来。有必要进行进一步研究，以了解认知功能障碍在神经功能障碍中表现明显的程度。
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