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2
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Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease.CRISPR/Cas9在脑发育和神经精神疾病研究中的应用。
Mol Cell Neurosci. 2017 Jul;82:157-166. doi: 10.1016/j.mcn.2017.05.007. Epub 2017 May 23.
2
DNA methylation controls unmethylated transcription start sites in the genome in trans.DNA甲基化以反式作用方式控制基因组中未甲基化的转录起始位点。
Epigenomics. 2017 May;9(5):611-633. doi: 10.2217/epi-2016-0141. Epub 2017 May 4.
3
Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis.重复性应激会导致认知功能受损,这与DNA低甲基化、脑源性神经营养因子减少以及下丘脑-垂体-肾上腺(HPA)轴失调有关。
Int J Dev Neurosci. 2017 Aug;60:63-69. doi: 10.1016/j.ijdevneu.2017.04.004. Epub 2017 Apr 29.
4
Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala.暴露于外部应激源、社会挫败或双酚A会消除杏仁核中DNA甲基转移酶表达的性别差异。
J Neuroendocrinol. 2017 Jun;29(6). doi: 10.1111/jne.12475.
5
Caregiver maltreatment causes altered neuronal DNA methylation in female rodents.照料者虐待会导致雌性啮齿动物的神经元DNA甲基化发生改变。
Dev Psychopathol. 2017 May;29(2):477-489. doi: 10.1017/S0954579417000128.
6
Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory.DNA甲基转移酶和组蛋白去乙酰化酶在单项和联想识别记忆中的不同作用。
Neuroepigenetics. 2017 Mar 6;9:1-9. doi: 10.1016/j.nepig.2017.02.001. eCollection 2017 Mar.
7
Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.成年大脑体内长期增强过程中突触可塑性基因的广泛启动子甲基化。
BMC Genomics. 2017 Mar 23;18(1):250. doi: 10.1186/s12864-017-3621-x.
8
Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring.子宫内暴露于母体应激会改变成年大鼠子代大脑中脑源性神经营养因子IV(Bdnf IV)的DNA甲基化和端粒长度。
Int J Dev Neurosci. 2017 Nov;62:56-62. doi: 10.1016/j.ijdevneu.2017.03.007. Epub 2017 Mar 19.
9
Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder.战斗相关创伤后应激障碍中脑源性神经营养因子基因的表观遗传改变
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10
An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk.儿童虐待与身心健康风险的表观遗传机制调查。
Dev Psychopathol. 2016 Nov;28(4pt2):1305-1317. doi: 10.1017/S0954579416000869. Epub 2016 Oct 3.

行为科学与脑科学中的表观遗传学进展与公共政策相关。

Epigenetic Advances in Behavioral and Brain Sciences have Relevance for Public Policy.

作者信息

Roth Tania L

机构信息

Department of Psychological and Brain Sciences, University of Delaware, Newark DE.

出版信息

Policy Insights Behav Brain Sci. 2017;4(2):202-209. doi: 10.1177/2372732217719091. Epub 2017 Aug 24.

DOI:10.1177/2372732217719091
PMID:29202007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5708565/
Abstract

Nature and nurture work together to drive development, behavior, and health. Behavioral epigenetics research has uncovered the underlying mechanisms for how this happens. Children's early years in development may offer the greatest opportunity for environmental and experiential factors to influence epigenome (chemical compounds telling our genes what to do), but evidence suggests it is never too late. The policy implications of this research are vast, including relevance for child development, health, and disease intervention and prevention.

摘要

先天因素和后天环境共同作用,推动着发育、行为和健康。行为表观遗传学研究揭示了其中的潜在机制。儿童发育的早期阶段可能为环境和经验因素影响表观基因组(告诉我们的基因该做什么的化合物)提供了最大的机会,但有证据表明,任何时候都不算晚。这项研究的政策影响广泛,包括与儿童发育、健康以及疾病干预和预防的相关性。