Ahmad Saeed, Rehman Tayyeba, Abbasi Waheed Mumtaz
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan; University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
J Ayurveda Integr Med. 2018 Jul-Sep;9(3):177-182. doi: 10.1016/j.jaim.2017.05.007. Epub 2017 Dec 6.
Homeopathy is a controversial alternative system of medicine. The action of homeopathic medicines is considered slow and it is assumed that homeopathic medicines are ineffective in acute conditions such as fever.
In the present study, effects of 3 homeopathic medicines on baker's yeast induced fever were investigated.
42 local strain rabbits were equally divided into 7 groups. Normal saline was orally administered to group 1 (normal control) rabbits without fever induction. Group 2 underwent baker's yeast-induced fever (negative control). Groups 3, 4, 5, 6 and 7 underwent baker's yeast-induced fever and were thereafter treated orally with paracetamol, Nux vomica 200C and 1M, Calcarea phos 200C and Belladonna 200C respectively. Rectal temperature was checked hourly. The abdominal writhing and frequency of loose stools were also monitored. ANOVA was applied for checking statistical significance. p ≤ 0.05 was considered significant.
The rectal temperature increased significantly (p < 0.05) in the negative control group when compared to the normal control. Abdominal writhing and loose stools monitoring showed increased writhing and loose stools frequency of group 2, 3, 6 and 7 rabbits. However, treatment of paracetamol significantly reduced rectal temperature. Group 4 & 5 showed significant reduction of rectal temperature together with abatement of abdominal writhing and loose stools.
N. vomica ultra-high dilutions have normalized rectal temperature and prevented the abdominal writhing and loose stools in baker's yeast-induced fever model of rabbits. It could be due to antidotal activity of N. vomica ultra-high dilutions. Therefore, N. vomica ultra-high dilutions can be useful antipyretic agents and can treat conditions associated with gastrointestinal symptoms. However, fixed conclusion can't be asserted due to caveat of small sample size.
顺势疗法是一种存在争议的替代医学体系。顺势疗法药物的作用被认为较为缓慢，并且人们假定顺势疗法药物在诸如发烧等急性病症中无效。
在本研究中，研究了3种顺势疗法药物对面包酵母诱导的发热的影响。
将42只本地品系兔子平均分为7组。对第1组（正常对照组）兔子口服生理盐水，不诱导发热。第2组进行面包酵母诱导的发热（阴性对照）。第3、4、5、6和7组进行面包酵母诱导的发热，之后分别口服对乙酰氨基酚、200C和1M的马钱子、200C的磷酸钙和200C的颠茄进行治疗。每小时检查直肠温度。还监测腹部绞痛和腹泻频率。应用方差分析来检验统计学意义。p≤0.05被认为具有显著性。
与正常对照组相比，阴性对照组的直肠温度显著升高（p<0.05）。腹部绞痛和腹泻监测显示，第2、3、6和7组兔子的绞痛和腹泻频率增加。然而，对乙酰氨基酚治疗显著降低了直肠温度。第4组和第5组显示直肠温度显著降低，同时腹部绞痛和腹泻减轻。
马钱子超高稀释液使兔子面包酵母诱导发热模型中的直肠温度恢复正常，并预防了腹部绞痛和腹泻。这可能归因于马钱子超高稀释液的解毒活性。因此，马钱子超高稀释液可能是有用的解热剂，并可治疗与胃肠道症状相关的病症。然而，由于样本量小的限制，无法得出确定的结论。
