Bonamin Leoni Villano, Endler Peter Christian
Laboratory of Cellular and Molecular Biology, University Paulista, Brazil.
Homeopathy. 2010 Jan;99(1):37-50. doi: 10.1016/j.homp.2009.11.003.
This is a systematic review of the animal models used in studies of high dilutions. The objectives are to analyze methodological quality of papers and reported results, and to highlight key conceptual aspects of high dilution to suggest clues concerning putative mechanisms of action.
Papers for inclusion were identified systematically, from the Pubmed-Medline database, using 'Homeopathy' and 'Animal' as keywords. Only original full papers in English published between January 1999 and June 2009 were included, reviews, scientific reports, thesis, older papers, papers extracted from Medline using similar keywords, papers about mixed commercial formulas and books were also considered for discussion only. 31 papers describing 33 experiments were identified for the main analysis and a total of 89 items cited.
Systematic analysis of the selected papers yielded evidence of some important intrinsic features of high dilution studies performed in animal models: a) methodological quality was generally adequate, some aspects could be improved; b) convergence between results and materia medica is seen in some studies, pointing toward to the possibility of systematic study of the Similia principle c) both isopathic and Similia models seem useful to understand some complex biological phenomena, such as parasite-host interactions; d) the effects of high dilutions seem to stimulate restoration of a 'stable state', as seen in several experimental models from both descriptive and mathematical points of view.
这是一篇对高稀释度研究中使用的动物模型的系统综述。目的是分析论文的方法学质量和报告的结果，并突出高稀释度的关键概念方面，以提示有关假定作用机制的线索。
使用“顺势疗法”和“动物”作为关键词，从Pubmed-Medline数据库中系统地识别纳入的论文。仅纳入1999年1月至2009年6月期间发表的英文原创全文，综述、科学报告、论文、旧论文、使用类似关键词从Medline中提取的论文、关于混合商业配方的论文和书籍仅作为讨论考虑。确定了31篇描述33项实验的论文用于主要分析，共引用了89项。
对所选论文的系统分析得出了在动物模型中进行的高稀释度研究的一些重要内在特征的证据：a）方法学质量总体上是足够的，某些方面可以改进；b）在一些研究中观察到结果与药物学之间的趋同，指向对“同类相治”原则进行系统研究的可能性；c）顺势疗法和同类相治模型似乎都有助于理解一些复杂的生物学现象，如寄生虫-宿主相互作用；d）从描述性和数学角度来看，在几个实验模型中都可以看到高稀释度的作用似乎刺激了“稳定状态”的恢复。
