Mohiyuddin S M Azeem, Padiyar B Vageesh, Suresh T N, Mohammadi Kouser, Sagayaraj A, Merchant Shuaib, Sultana Azeem Mahnaaz
Department of Otorhinolaryngology and Head and Neck Surgery, Sri Devaraj Urs Medical College, Tamaka, Kolar 563101, India.
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar 563101, India.
World J Otorhinolaryngol Head Neck Surg. 2016 Mar 31;2(1):17-21. doi: 10.1016/j.wjorl.2016.02.003. eCollection 2016 Mar.
To evaluate the margins of resected specimen of oral squamous cell carcinoma (SCC) and to document the surgical margin (measured at the time of resection) and margins at the time of pathological examination (after immersion of the specimen in formalin).
Patients who were diagnosed and confirmed with squamous carcinoma of buccal mucosa were included in the study. Patients underwent resection of the tumor with a margin of 1 cm. Soon after resection, the distance between outermost visible margin of the tumor and the margin of the specimen was measured and documented. Specimens were fixed in 10% formalin and submitted for gross and histopathological examination. The closest histopathologic margin was compared with the in situ margin (10 mm) to determine and document any shrinkage of the margin and the percentage of discrepancy if any.
A total of 52 specimens were collected from patients between January 2014 and December 2014. All specimens were obtained from the oral cavity (n = 52) of which 43 (82.7%) were squamous cell carcinoma and 9 (17.3%) were verrucous variant of squamous cell carcinoma. The average decrease in tumor margins measured after fixation in formalin was found to be statistically significant ( < 0.05) in 65% of cases.
Tumor margin shrinks significantly after formalin fixation by about 25%. The operating surgeon and pathologist should be well aware of such changes while planning for further management thereby ensuring adequate margin of resection and adjuvant treatment wherever required to prevent possible local recurrence of the disease.
评估口腔鳞状细胞癌（SCC）切除标本的切缘，并记录手术切缘（切除时测量）及病理检查时（标本浸泡于福尔马林后）的切缘情况。
本研究纳入经诊断并确诊为颊黏膜鳞状细胞癌的患者。患者接受肿瘤切除，切缘为1厘米。切除后不久，测量并记录肿瘤最外侧可见边缘与标本边缘之间的距离。标本固定于10%福尔马林后进行大体及组织病理学检查。将最接近的组织病理学切缘与原位切缘（10毫米）进行比较，以确定并记录切缘的任何收缩情况以及如有差异的百分比。
2014年1月至2014年12月期间共收集了52份患者标本。所有标本均取自口腔（n = 52），其中43份（82.7%）为鳞状细胞癌，9份（17.3%）为鳞状细胞癌疣状变体。在65%的病例中，福尔马林固定后测量的肿瘤切缘平均缩小具有统计学意义（<0.05）。
福尔马林固定后肿瘤切缘显著缩小约25%。手术医生和病理医生在规划进一步治疗时应充分意识到此类变化，从而确保切除切缘足够，并在需要时进行辅助治疗，以防止疾病可能的局部复发。
