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男性泌尿生殖系统恶性肿瘤的尿微生物组特征。

Urinary microbiome profile in men with genitourinary malignancies.

机构信息

Department of Urology, Ewha Womans University Seoul Hospital, Seoul, Korea.

3BIGS CO., LTD., Hwaseong, Korea.

出版信息

Investig Clin Urol. 2022 Sep;63(5):569-576. doi: 10.4111/icu.20220124.

DOI:10.4111/icu.20220124
PMID:36068003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9448674/
Abstract

PURPOSE

Recent advances in molecular biology technology have allowed identification of microbial communities in the urinary tract, and urinary microbiome is associated with various urological diseases. In this study, we aimed to characterize the urinary microbiome of genitourinary malignancies.

MATERIALS AND METHODS

Metagenomic analysis of urinary DNA was performed in 85 patients including 30 with bladder cancer (BC), 27 with prostate cancer (PC), 12 with renal cancer (RC), and 16 with non-cancer (NC). 16S rRNA gene sequencing was conducted after amplification of the V3-V4 region.

RESULTS

PC and RC had significantly lower Shannon index than BC, and beta diversity showed significantly different microbiome composition between four groups. We identified six genera of , , , , , and , which showed significantly different abundance between the four groups. When each of the malignancies were compared to NC at the species level, sp. was significantly increased in BC. We also identified 12 and five species with increased populations in PC and RC, respectively. Of these, , , , and were significantly increased in both PC and RC.

CONCLUSIONS

Urinary microbiome composition was different depending on the type of genitourinary malignancies, and we identified bacteria that are significantly associated with each type of malignancy. Specifically, several bacterial species were associated both PC and RC, suggesting that PC and RC share a similar pathogenesis-related urinary microbiome.

摘要

目的

分子生物学技术的最新进展使得能够鉴定尿路感染中的微生物群落，而尿微生物组与各种泌尿科疾病有关。在这项研究中，我们旨在描述泌尿生殖系统恶性肿瘤的尿微生物组。

材料和方法

对 85 名患者的尿液 DNA 进行了宏基因组分析，其中包括 30 名膀胱癌 (BC) 患者、27 名前列腺癌 (PC) 患者、12 名肾癌 (RC) 患者和 16 名非癌症 (NC) 患者。扩增 V3-V4 区后进行 16S rRNA 基因测序。

结果

PC 和 RC 的 Shannon 指数明显低于 BC，β多样性显示四组之间的微生物组组成存在显著差异。我们鉴定出了 、 、 、 、 和 六个属，它们在四组之间的丰度存在显著差异。当将每种恶性肿瘤与 NC 在种水平上进行比较时，BC 中 sp. 的丰度明显增加。我们还在 PC 和 RC 中分别鉴定出了 12 种和 5 种种群增加的物种。其中， 、 、 、 和 在 PC 和 RC 中均明显增加。

结论

尿微生物组组成因泌尿生殖系统恶性肿瘤的类型而异，我们鉴定出了与每种恶性肿瘤显著相关的细菌。具体来说，几种细菌与 PC 和 RC 均相关，提示 PC 和 RC 具有相似的发病机制相关的尿微生物组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/c6a7acf1202e/icu-63-569-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/01b2de3c03eb/icu-63-569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/47e3773241dc/icu-63-569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/66a1887107fb/icu-63-569-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/c6a7acf1202e/icu-63-569-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/01b2de3c03eb/icu-63-569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/47e3773241dc/icu-63-569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/66a1887107fb/icu-63-569-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26f/9448674/c6a7acf1202e/icu-63-569-g004.jpg

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