Balaa M A
Medical Service, Jackson VA Medical Center, Mississippi 39216.
Dig Dis Sci. 1989 Mar;34(3):429-35. doi: 10.1007/BF01536267.
The factors responsible for the mediation of mild irritant-induced (adaptive) cytoprotection to the rat stomach are not fully understood. The existence of cytoprotective products that are released by the gastric mucosa in response to its exposure to a mild irritant is assessed in this work. Gastric contents of rats exposed to a mild irritant (0.3 N HCl) or to 0.3 N NaCl (control) were collected, titrated to neutrality, and administered orally to prefasted animals followed by 100% ethanol. Ethanol-induced gross hemorrhagic injury in rats pretreated with the 0.3 N HCl gastric contents were significantly less than in control treated rats (P less than 0.01). Pretreating the donor or recipient rats with indomethacin did not interfere with the generation or protective action of the 0.3 N HCl gastric contents. These findings demonstrate that the exposure of the gastric mucosa to a mild irritant causes the release of protective products, which are different from prostaglandins, into the gastric lumen.
导致大鼠胃对轻度刺激物诱导的（适应性）细胞保护作用进行介导的因素尚未完全明确。本研究评估了胃黏膜在接触轻度刺激物后释放的细胞保护产物的存在情况。收集暴露于轻度刺激物（0.3 N盐酸）或0.3 N氯化钠（对照）的大鼠的胃内容物，滴定至中性，然后口服给禁食的动物，随后给予100%乙醇。用0.3 N盐酸胃内容物预处理的大鼠中，乙醇诱导的严重出血性损伤明显少于对照处理的大鼠（P小于0.01）。用吲哚美辛预处理供体或受体大鼠并不干扰0.3 N盐酸胃内容物的产生或保护作用。这些发现表明，胃黏膜暴露于轻度刺激物会导致不同于前列腺素的保护产物释放到胃腔中。
