Jeon Da-Hye, Yeom Hyungseon, Yang Jaewon, Song Jong Suk, Lee Hyung Keun, Kim Hyeon Chang
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Prev Med Public Health. 2017 Nov;50(6):369-376. doi: 10.3961/jpmph.17.089.
Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI).
The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI.
Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations.
The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.
干眼症（DED）在韩国是一个日益重要的公共卫生问题。此前在韩国进行的研究报告了维生素D对干眼症保护作用的结果不一致，这些差异可能与所使用的相对简单的调查问卷有关。因此，我们使用眼表疾病指数（OSDI）评估血清维生素D水平与干眼症的关联。
本研究评估了环境眼病研究组（2014 - 2015年）参与者的数据。该组包括752名参与者的数据，本研究分析了740名参与者（253名男性和487名女性）的数据。使用OSDI评估干眼症严重程度。
在粗分析中（优势比[OR]，0.991；95%置信区间[CI]，0.971至1.011）和调整分析中（OR，0.988；95% CI，0.966至1.010），较高的血清维生素D水平与干眼症风险非显著降低相关。在无/轻度干眼症与中度/重度干眼症的粗分析中，男性随着血清维生素D水平升高风险降低（OR，0.999；95% CI，0.950至1.051），而女性风险增加（OR，1.003；95% CI，0.979至1.027）。在这些分析中，我们未发现显著关联。
本研究结果支持先前的报告，即血清维生素D水平与干眼症无关。
