Zhang Tie-Ning, Li Da, Xia Jing, Wu Qi-Jun, Wen Ri, Yang Ni, Liu Chun-Feng
Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Oncotarget. 2017 Oct 10;8(53):91765-91778. doi: 10.18632/oncotarget.21766. eCollection 2017 Oct 31.
Sepsis, a syndrome of physiologic, pathologic, and biochemical abnormalities caused by an altered systemic host response to infection, has become the main cause of death among patients admitted to the intensive care units. Recently, genome-wide expression analysis revealed that over 80% of the essential genetic elements were altered in critically ill patients. Notably, non-coding RNAs, including microRNAs, long non-coding RNAs and circular RNAs, have been proven to play essential roles in innate immunity, mitochondrial dysfunction and organ dysfunction. In this review, we introduced the biogenesis of non-coding RNAs briefly and summed up different kinds of non-coding RNAs in regulation of sepsis, which could provide a more comprehensive understanding about pathogenesis of the disease. Additionally, we summarized the limitations of current biomarkers and then recommended some non-coding RNAs as novel potential biomarkers for sepsis and sepsis-induced organ dysfunction. Besides, we also introduced some problems and challenges that need to be overcome during the clinical application of non-coding RNAs. Future research should focus on elucidating their molecular mechanisms, particularly long non-coding RNAs as well as circular RNAs and sepsis, to further understanding of the disease process. With the in-depth understanding of the mechanism of sepsis, non-coding RNAs provide a new insight into sepsis and could become the novel therapeutic targets in the future.
脓毒症是一种由全身宿主对感染的反应改变所引起的生理、病理和生化异常综合征，已成为重症监护病房患者死亡的主要原因。最近，全基因组表达分析显示，超过80%的必需基因元件在危重病患者中发生了改变。值得注意的是，包括微小RNA、长链非编码RNA和环状RNA在内的非编码RNA已被证明在先天免疫、线粒体功能障碍和器官功能障碍中起重要作用。在本综述中，我们简要介绍了非编码RNA的生物合成，并总结了不同类型的非编码RNA在脓毒症调控中的作用，这有助于更全面地了解该疾病的发病机制。此外，我们总结了当前生物标志物的局限性，然后推荐了一些非编码RNA作为脓毒症和脓毒症诱导的器官功能障碍的新型潜在生物标志物。此外，我们还介绍了非编码RNA临床应用过程中需要克服的一些问题和挑战。未来的研究应侧重于阐明它们的分子机制，特别是长链非编码RNA以及环状RNA与脓毒症的关系，以进一步了解疾病过程。随着对脓毒症机制的深入了解，非编码RNA为脓毒症提供了新的见解，并可能在未来成为新的治疗靶点。
