School of Life and Medical Sciences, Faculty of Population Health Sciences, Institute for Global Health, University College London, WC1E 6BT, London, UK.
Galactic Corps Research Group (GCRG), Buea, Cameroon.
Syst Rev. 2017 Dec 6;6(1):247. doi: 10.1186/s13643-017-0650-0.
Several studies have reported on factors influencing adolescent pregnancies and the associated outcomes, but evidence from a systematic review is limited, especially in sub-Saharan Africa where the greater burden lies. Establishment of accurate epidemiological data on the rates of adolescent pregnancy, its predictors, and adverse outcomes (maternal and neonatal) may have important implications towards attainment of the Sustainable Development Goals.
This will be a systematic review of studies reporting predictors of adolescent pregnancy and adverse outcomes in sub-Saharan Africa published between January 2000 and December 2017. The following databases will be searched: PubMed/MEDLINE, Excerpta Medica Database (EMBASE), SCOPUS, Popline, Africa Wide Information, African Index Medicus, Google scholar and the Cochrane library. Three authors will independently screen all potential articles for eligibility as guided by the selection criteria. The Stata statistical software will be used in analysing the data. Appropriate meta-analytic techniques will be used to pool prevalence estimates from studies with similar features, overall and by major subgroups as warranted. Heterogeneity of studies will be evaluated by the χ test on Cochrane's Q statistic. Publication bias will be sorted for using funnel plot analysis and Egger's test. Qualitative synthesis will be used where data are insufficient to produce a quantitative synthesis. This protocol is reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) 2015 guidelines.
This systematic review and meta-analysis is expected to serve as a template for designing adolescent-friendly preventive and control programmes to help curb the ever-growing burden of adolescent pregnancies, and as a guide for future research.
PROSPERO CRD42017070773.
有几项研究报告了影响青少年怀孕及其相关后果的因素，但系统评价的证据有限，尤其是在撒哈拉以南非洲，该地区的负担更重。准确建立关于青少年怀孕率、其预测因素和不良后果（产妇和新生儿）的流行病学数据，可能对实现可持续发展目标具有重要意义。
这将是一项对 2000 年 1 月至 2017 年 12 月期间在撒哈拉以南非洲地区发表的报告青少年怀孕及其不良后果预测因素的研究的系统评价。将搜索以下数据库：PubMed/MEDLINE、Excerpta Medica Database（EMBASE）、SCOPUS、Popline、Africa Wide Information、African Index Medicus、Google scholar 和 Cochrane 图书馆。将根据选择标准，由三位作者独立筛选所有潜在的符合入选条件的文章。将使用 Stata 统计软件分析数据。将使用适当的荟萃分析技术汇总具有相似特征的研究的患病率估计值，如有必要，将按主要亚组进行汇总。研究的异质性将通过 Cochrane 的 Q 统计量的 χ 2 检验进行评估。将使用漏斗图分析和 Egger 检验来评估发表偏倚。在数据不足以进行定量综合的情况下，将使用定性综合。本方案按照系统评价和荟萃分析优先报告项目（PRISMA-P）2015 指南进行报告。
这项系统评价和荟萃分析有望成为设计青少年友好型预防和控制方案的模板，以帮助遏制日益增长的青少年怀孕负担，并为未来的研究提供指导。
PROSPERO CRD42017070773。
