非洲肺动脉高压的患病率、发病率及病因：一项系统评价和荟萃分析方案

Prevalence, incidence and aetiologies of pulmonary hypertension in Africa: a systematic review and meta-analysis protocol.

作者信息

Bigna Jean Joel, Noubiap Jean Jacques, Nansseu Jobert Richie, Aminde Leopold Ndemnge

机构信息

Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaoundé, Cameroon.

School of Public Health, Faculty of Medicine, University of Paris Sud XI, Le Kremlin Bicêtre, France.

出版信息

BMJ Open. 2017 Jun 16;7(6):e014768. doi: 10.1136/bmjopen-2016-014768.

DOI:10.1136/bmjopen-2016-014768

PMID:28624758

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5623436/

Abstract

INTRODUCTION

There are no data summarising the epidemiology of pulmonary hypertension (PH) among adults residing in Africa. Establishment of accurate epidemiological data on PH in this region may guide decision-making toward interventions to curb the burden of PH in Africa. The aim of this systematic review is to determine the prevalence, incidence and aetiologies of PH among people residing in Africa.

METHODS AND ANALYSIS

This systematic review and meta-analysis will follow the MOOSE guidelines for reporting. Relevant abstracts published until 30 September 2016 will be searched in PubMed/Medline, EMBASE (Excerpta Medica Database), African Journals Online and Africa Index Medicus. Full texts of eligible studies will then be accessed through PubMed, Google Scholar, HINARI and the respective journals' websites. Relevant unpublished papers and conference proceedings will also be checked. Data will be analysed using STATA version 13 software. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence/incidence and aetiologies of PH across studies. Heterogeneity of studies will be evaluated by the χ test on Cochrane's Q statistic. Funnel plot analysis and Egger's test will be done to detect publication bias. Results will be presented by geographical region (central, eastern, northern, southern and western Africa).

ETHICS AND DISSEMINATION

The current study is based on published data; ethical approval is, therefore, not required. This review will guide policy, practice and research by providing information on the magnitude of PH among people residing in Africa. Findings will be presented in evidence tables of individual studies as well as in summary tables. The final report of this systematic review, in the form of a scientific paper, will be published in a peer-reviewed journal. Furthermore, findings will be presented at conferences and submitted to relevant health authorities.

REVIEW REGISTRATION NUMBER

PROSPERO CRD42016049351.

摘要

引言

目前尚无关于居住在非洲的成年人肺动脉高压（PH）流行病学的数据总结。建立该地区PH的准确流行病学数据可能有助于指导决策，以采取干预措施减轻非洲地区PH的负担。本系统评价的目的是确定居住在非洲人群中PH的患病率、发病率及病因。

方法与分析

本系统评价和荟萃分析将遵循MOOSE报告指南。在PubMed/Medline、EMBASE（医学文摘数据库）、非洲在线期刊和非洲医学索引中检索截至2016年9月30日发表的相关摘要。然后通过PubMed、谷歌学术、HINARI和各期刊网站获取符合条件研究的全文。还将检查相关未发表的论文和会议记录。使用STATA 13软件进行数据分析。将通过随机效应荟萃分析模型汇总各研究的特定估计值，以获得各项研究中PH患病率/发病率及病因的总体汇总估计值。通过对Cochrane Q统计量进行χ检验评估研究的异质性。将进行漏斗图分析和Egger检验以检测发表偏倚。结果将按地理区域（非洲中部、东部、北部、南部和西部）呈现。