在一个患有夏科-马里-图思病的大家族中，对达菲血型标记与1号染色体上几个基因进行连锁分析。
Linkage analysis of the Duffy blood group marker with several chromosome 1 genes in an extended pedigree with Charcot-Marie-Tooth disease.
作者信息
Raeymaekers P, Van Broeckhoven C, Backhovens H, Wehnert A, Muylle L, De Jonghe P, Gheuens J, Martin J J, Vandenberghe A
机构信息
Department of Biochemistry, University of Antwerpen, Belgium.
出版信息
Hum Genet. 1989 Feb;81(3):231-3. doi: 10.1007/BF00278994.
We have recently demonstrated tight linkage of the Duffy blood group marker to the alpha-spectrin gene in an extended pedigree with Charcot-Marie-Tooth neuropathy. To determine a more precise location of the Duffy blood group locus on the chromosome 1 map we have tested several more chromosome 1 genes for linkage with this marker. We found suggestive linkage with the antithrombin III and apolipoprotein A2 genes and conclusive linkage with the gene coding for beta-nerve growth factor.
我们最近在一个患有夏科-马里-图斯神经病的大家族中证实，达菲血型标记与α-血影蛋白基因紧密连锁。为了在1号染色体图谱上确定达菲血型位点更精确的位置，我们又检测了另外几个1号染色体基因与该标记的连锁情况。我们发现抗凝血酶III和载脂蛋白A2基因存在提示性连锁，与β-神经生长因子编码基因存在确定性连锁。
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