人类多位点连锁分析：连锁检测与重组估计
Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.
作者信息
Lathrop G M, Lalouel J M, Julier C, Ott J
出版信息
Am J Hum Genet. 1985 May;37(3):482-98.
Abstract
Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.
摘要
从检测连锁和确定连锁群内基因顺序的不同策略下重组估计效率的角度，对多位点连锁分析进行了研究。我们考虑了在人类遗传学研究中对现有数据假设无干扰的合理性。给出了一些例子来说明多位点分析在人类研究中的重要性。描述了一个用于多位点连锁分析的计算机程序包LINKAGE。
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