采用基于有机硅烷的策略对海鞘素 8 进行全合成。
Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, China.
出版信息
Angew Chem Int Ed Engl. 2018 Jan 22;57(4):942-946. doi: 10.1002/anie.201711452. Epub 2017 Dec 20.
Convergent total synthesis of bryostatin 8 has been accomplished by an organosilane-based strategy. The C ring is constructed stereoselectively through a geminal bis(silane)-based [1,5]-Brook rearrangement, and the B ring through geminal bis(silane)-based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule.
通过基于有机硅烷的策略，实现了 bryostatin 8 的会聚全合成。C 环通过偕二（硅烷）基[1,5]-Brook 重排立体选择性构建，B 环通过偕二（硅烷）基 Prins 环化构建，从而有效地连接了分子的北部和南部。
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