Choi Jeong In, Chae Song Ji, Kim Jung Min, Choi Jae Chun, Park Se Jong, Choi Hee Ju, Bae Hojae, Park Hyun Jin
a Department of Biotechnology, College of Life Science and Biotechnology , Korea University , Seoul , Republic of Korea.
b Food Additives and Packaging Division , National Institute of Food and Drug Safety Evaluation , Osong , Republic of Korea.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 May;35(5):996-1005. doi: 10.1080/19440049.2017.1411611. Epub 2018 Jan 15.
In recent years, silver nanoparticles (AgNPs) have been extensively employed in food packaging systems as a potential antibacterial agent. Although proven to be highly effective, the increased number of AgNP-containing products raises concerns among consumers regarding the migration of AgNPs from the packaging material into foods, which may exert toxic effects. To address this, five baby products were chosen (baby bottle A, baby bottle B, pacifier A, pacifier B and breastmilk storage bag) to investigate AgNPs migration into three food simulants (deionised water, 4% acetic acid (w/v) and 50% ethanol (v/v)) using inductively coupled plasma mass spectrometry (ICP-MS). As a result, the highest level of migrated Ag was observed for 4% acetic acid in the case of baby bottle B, pacifier A, pacifier B and the breastmilk storage bag, with the detection amount ranging from 1.05-2.25 ng/mL. On the other hand, baby bottle A showed the maximum migration for 50% ethanol due to the polymer nature. Finally, a centrifugal ultrafiltration experiment was conducted to determine the fraction of dissolved Ag in acidic simulant and it was found that migrated Ag was predominantly in Ag form, with a small fraction of non-ionic AgNPs. Thus, it has been found that the amount of migrated Ag in baby products was low; however, the migration was dependent on the type of food simulant and polymer nature.
近年来，银纳米颗粒（AgNPs）作为一种潜在的抗菌剂已被广泛应用于食品包装系统。尽管已证明其高效性，但含AgNP产品数量的增加引发了消费者对AgNPs从包装材料迁移到食品中可能产生毒性作用的担忧。为解决这一问题，选取了五种婴儿产品（婴儿奶瓶A、婴儿奶瓶B、安抚奶嘴A、安抚奶嘴B和母乳储存袋），使用电感耦合等离子体质谱法（ICP-MS）研究AgNPs向三种食品模拟物（去离子水、4%乙酸（w/v）和50%乙醇（v/v））中的迁移情况。结果显示，在婴儿奶瓶B、安抚奶嘴A、安抚奶嘴B和母乳储存袋的情况下，4%乙酸中迁移的Ag含量最高，检测量在1.05 - 2.25 ng/mL之间。另一方面，由于聚合物性质，婴儿奶瓶A在50%乙醇中的迁移量最大。最后，进行了离心超滤实验以确定酸性模拟物中溶解Ag的比例，发现迁移的Ag主要以Ag形式存在，只有一小部分是非离子型AgNPs。因此，已发现婴儿产品中迁移的Ag量较低；然而，迁移量取决于食品模拟物的类型和聚合物性质。
