Teo P, Tai T H, Choy D
Clinical Oncology Department, Prince of Wales Hospital, Shatin, Hong Kong.
Int J Radiat Oncol Biol Phys. 1989 Feb;16(2):471-4. doi: 10.1016/0360-3016(89)90344-1.
From 1976 to 1986, ten out of 1154 consecutive nasopharyngeal carcinoma (NPC) patients were found to have dermatomyositis (DM). Their clinical features and treatment results were analyzed. The skin manifestation was typical of DM and myopathy occurred in seven patients. All the tumor on presentation were early stage and locoregional control after radiotherapy was satisfactory. All but one patient had DM prior to diagnosis of NPC. The prognosis of NPC was not affected by DM with survival being comparable to contemporary controls. The complication of radiotherapy were unusually severe. Chronic radiation skin ulceration occurred in 2 patients and subcutaneous indurated fibrosis affecting both sides of neck occurred in all patients. Acute radiation mucositis was also prominent.
1976年至1986年期间，在1154例连续的鼻咽癌（NPC）患者中，有10例被发现患有皮肌炎（DM）。对他们的临床特征和治疗结果进行了分析。皮肤表现为典型的皮肌炎，7例患者出现了肌病。所有初诊时的肿瘤均为早期，放疗后局部区域控制情况良好。除1例患者外，所有患者在鼻咽癌诊断之前就已患有皮肌炎。鼻咽癌的预后不受皮肌炎影响，生存率与同期对照组相当。放疗并发症异常严重。2例患者出现慢性放射性皮肤溃疡，所有患者均出现影响颈部两侧的皮下硬结性纤维化。急性放射性口腔炎也很突出。
