Tran Phi Hung, Le Viet Dung, Do Thi Ha, Nguyen Thi Luyen, Nguyen Phuong Thao, Nguyen Trong Thong, Nguyen Tien Dat
a Department of Phytochemistry , National Institute of Medicinal Materials , Hanoi , Vietnam.
b Department of Pharmacy , National Hospital of Traditional Medicine , Hanoi , Vietnam.
Nat Prod Res. 2019 Mar;33(5):695-700. doi: 10.1080/14786419.2017.1408095. Epub 2017 Dec 6.
One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.
从石上蜈蚣地上部分的乙醇提取物中分离得到了1个新化合物和3个已知化合物。通过光谱方法，确定它们的结构分别为去乙酰车叶草苷酸6-乙醚（1）、车叶草苷酸（2）、车叶草苷（3）和奥图卡巴酯C（4）。对分离得到的化合物进行了评估，考察其对脂多糖刺激的RAW264.7细胞中一氧化氮产生的抑制作用。其中，化合物2和4表现出较强的抑制作用，IC值分别为5.75±0.85和6.92±0.43μM。这是关于石上蜈蚣化学成分和生物活性的首次报道。
