a Faculty of Pharmacy, Department of Pharmacognosy , Yeditepe University , İstanbul , Turkey.
b Faculty of Pharmacy, Department of Toxicology , Yeditepe University , İstanbul , Turkey.
Nat Prod Res. 2019 Sep;33(17):2541-2544. doi: 10.1080/14786419.2018.1448815. Epub 2018 Mar 12.
Phytochemical investigations on the EtOH extract of led to the isolation of six flavonoid glycosides, isoorientin (), isoorientin 3'--methyl ether (), quercetin 7--α-L-rhamnopyranoside (), quercetin 3,7-di--α-L-rhamnopyranoside (), manghaslin () and chrysoeriol 7--β-D-glucopyranoside (), one phenylethanol derivative, hydroxytyrosol (), along with three phenolic acids, caffeic acid (), ()--coumaric acid () and -hydroxybenzoic acid (). The structures of the isolates were elucidated on the basis of NMR and HR-MS data. All compounds were isolated from for the first time. Compounds and showed significant anti-inflammatory activity at 100 μM by reducing the release of NO in LPS-stimulated macrophages comparable to positive control indomethacin. Compounds and exhibited anti-inflammatory activity through lowering the levels of TNF-α while , and decreased the levels of neopterin better than the positive controls.
植物化学研究表明，从 led 的乙醇提取物中分离得到了六种黄酮糖苷，分别为异荭草苷（）、异荭草苷 3'-O-甲基醚（）、槲皮素 7-O-α-L-鼠李糖苷（）、槲皮素 3,7-二-O-α-L-鼠李糖苷（）、芒果苷（）和芫花素 7-O-β-D-吡喃葡萄糖苷（），一个苯乙醇衍生物，羟基酪醇（），以及三种酚酸，咖啡酸（）、（）-阿魏酸（）和 - 羟基苯甲酸（）。根据 NMR 和 HR-MS 数据，鉴定了这些分离物的结构。所有化合物均首次从 中分离得到。化合物 和 在 100 μM 时通过降低 LPS 刺激的巨噬细胞中 NO 的释放，表现出显著的抗炎活性，与阳性对照吲哚美辛相当。化合物 和 通过降低 TNF-α 的水平表现出抗炎活性，而 、 和 降低了 Neopterin 的水平，优于阳性对照。
