乳腺癌组织中的类蛋白酶样肽酶活性和雌激素受体水平。
Proteinase-like peptidase activities and oestrogen receptor levels in breast cancer tissue.
作者信息
Vasishta A, Baker P R, Preece P E, Wood R A, Cuschieri A
机构信息
University Department of Surgery, Ninewells Hospital and Medical School, Dundee, Scotland.
出版信息
J Cancer Res Clin Oncol. 1989;115(1):89-92. doi: 10.1007/BF00391606.
The relationship between proteinase-like peptidase activities and oestrogen receptor levels and status in breast cancer tissue homogenates from 61 patients with breast cancer has been evaluated. With Spearman's rank-order correlation analysis, significant positive correlations were observed between receptor levels and the activities of cathepsin-(B + L)-like, cathepsin-H-like, trypsin-like, plasminogen-activator-like and elastase-like peptidases. In addition, the activities of all but the latter enzyme were significantly higher in patients with receptor-rich tumours than in receptor-poor tumours, and this may have implications for future treatment regimens for patients with oestrogen-receptor-rich tumours. The findings reported are consistent with the suggestion that in breast cancer there may be an association between steroid receptors and proteolytic enzymes such that the release of these enzymes may be under hormonal control.
对61例乳腺癌患者的乳腺癌组织匀浆中类蛋白酶样肽酶活性与雌激素受体水平及状态之间的关系进行了评估。通过Spearman等级相关分析，观察到受体水平与组织蛋白酶-（B+L）样、组织蛋白酶-H样、胰蛋白酶样、纤溶酶原激活剂样和弹性蛋白酶样肽酶的活性之间存在显著正相关。此外，除后一种酶外，所有酶的活性在受体丰富的肿瘤患者中显著高于受体缺乏的肿瘤患者，这可能对雌激素受体丰富的肿瘤患者的未来治疗方案有影响。报道的研究结果与以下观点一致：在乳腺癌中，类固醇受体与蛋白水解酶之间可能存在关联，使得这些酶的释放可能受激素控制。
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