Marshall Sarah A, Hannan Natalie J, Jelinic Maria, Nguyen Thy P H, Girling Jane E, Parry Laura J
School of BioSciences, The University of Melbourne , Parkville, Victoria , Australia.
The Translational Obstetrics Group, Mercy Hospital for Women, Department of Obstetrics and Gynaecology, The University of Melbourne , Victoria , Australia.
Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R499-R508. doi: 10.1152/ajpregu.00355.2017. Epub 2017 Dec 6.
Preeclampsia affects up to 8% of pregnancies worldwide and is a leading cause of both maternal and fetal morbidity and mortality. Our current understanding of the cause(s) of preeclampsia is far from complete, and the lack of a single reliable animal model that recapitulates all aspects of the disease further confounds our understanding. This is partially due to the heterogeneous nature of the disease, coupled with our evolving understanding of its etiology. Nevertheless, animal models are still highly relevant and useful tools that help us better understand the pathophysiology of specific aspects of preeclampsia. This review summarizes the various types and characteristics of animal models used to study preeclampsia, highlighting particular features of these models relevant to clinical translation. This review points out the strengths and limitations of these models to illustrate the importance of using the appropriate model depending on the research question.
子痫前期影响全球多达8%的妊娠，是孕产妇和胎儿发病及死亡的主要原因。我们目前对子痫前期病因的理解还远远不够全面，而且缺乏一个能概括该疾病所有方面的单一可靠动物模型，这进一步混淆了我们的认识。部分原因在于该疾病的异质性，以及我们对其病因不断演变的理解。尽管如此，动物模型仍然是高度相关且有用的工具，有助于我们更好地理解子痫前期特定方面的病理生理学。本综述总结了用于研究子痫前期的各种动物模型的类型和特征，突出了这些模型与临床转化相关的特定特征。本综述指出了这些模型的优势和局限性，以说明根据研究问题使用合适模型的重要性。
