van Winkelhoff A J, Rodenburg J P, Goené R J, Abbas F, Winkel E G, de Graaff J
Department of Oral Microbiology, Academic Center for Dentistry, Amsterdam (ACTA), The Netherlands.
J Clin Periodontol. 1989 Feb;16(2):128-31. doi: 10.1111/j.1600-051x.1989.tb01626.x.
The potential use of an adjunctive therapy of metronidazole plus amoxycillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated. 22 patients participated in this study, 11 with localized juvenile periodontitis (LJP) and 11 with rapidly progressive periodontitis (RPP). 14 patients had received periodontal treatment in the past. All patients were subgingivally infected with A. actinomycetemcomitans. After mechanical subgingival debridement in combination with the antibiotic treatment, elimination of A. actinomycetemcomitans was achieved in all patients but one. With this one exception, clinical improvements were observed in all patients, resulting in reduced pocket probing depths as well as in a significant reduction in bleeding on probing. Re-examination of 16 patients after 9-11 months revealed that A. actinomycetemcomitans was still undetectable and further clinical improvement was observed. It was concluded that the combination of metronidazole plus amoxycillin is a valuable adjunct to mechanical therapy in A. actinomycetemcomitans associated periodontal infections.
研究了甲硝唑加阿莫西林辅助治疗对牙周炎患者龈下放线杆菌消除的潜在作用。22名患者参与了本研究，其中11名患有局限性青少年牙周炎（LJP），11名患有快速进展性牙周炎（RPP）。14名患者过去接受过牙周治疗。所有患者龈下均感染了放线杆菌。在进行龈下机械清创术并结合抗生素治疗后，除一名患者外，所有患者的放线杆菌均被清除。除这一例外，所有患者均观察到临床改善，导致牙周袋探诊深度减小以及探诊出血显著减少。9 - 11个月后对16名患者进行复查发现，仍未检测到放线杆菌，并且观察到进一步的临床改善。得出结论，甲硝唑加阿莫西林联合用药是治疗放线杆菌相关牙周感染的机械治疗的一种有价值的辅助手段。
