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单纯疱疹病毒 2 型（HSV-2）单周期候选疫苗在糖蛋白 D 缺失后可保护雄性小鼠免受 HSV-1 和 HSV-2 临床分离株的致死性皮肤攻击。

A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2.

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York.

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York.

出版信息

J Infect Dis. 2018 Feb 14;217(5):754-758. doi: 10.1093/infdis/jix628.

DOI:10.1093/infdis/jix628
PMID:29216362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5853290/
Abstract

Herpes simplex virus (HSV) infections manifest as recurrent oral or genital mucosal lesions, meningoencephalitis, corneal blindness, and perinatal disease. Subunit vaccines have advanced into the clinic without success. None were tested preclinically in male mice. We compared a single-cycle candidate vaccine deleted in HSV-2 glycoprotein D (ΔgD-2) and subunit gD-2 or gD-1 protein vaccines in a male murine skin model. The ΔgD-2 provided complete protection against 10 times the lethal dose of HSV-1 or HSV-2 clinical isolates, and no latent virus was detected, whereas gD-1- and gD-2-adjuvanted proteins provided little or no protection. Protection correlated with Fc receptor activating but not neutralizing antibody titers.

摘要

单纯疱疹病毒 (HSV) 感染表现为复发性口腔或生殖器黏膜病变、脑膜炎脑炎、角膜盲和围产期疾病。亚单位疫苗已进入临床阶段，但未成功。在雄性小鼠中，没有一种疫苗在临床前进行过测试。我们在雄性小鼠皮肤模型中比较了一种单周期候选疫苗（缺失 HSV-2 糖蛋白 D (ΔgD-2) 的疫苗）和亚单位 gD-2 或 gD-1 蛋白疫苗。ΔgD-2 对 10 倍致死剂量的 HSV-1 或 HSV-2 临床分离株提供完全保护，未检测到潜伏病毒，而 gD-1 和 gD-2 佐剂蛋白提供的保护很少或没有。保护与 Fc 受体激活而不是中和抗体滴度相关。

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Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge.在接种疫苗的雌性恒河猴而非雄性恒河猴中，经SIVmac251直肠攻击后，黏膜B细胞与SIV感染延迟相关。
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Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins.人疱疹病毒1型和2型糖蛋白内部及之间的全球多样性
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Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012.2012年全球单纯疱疹病毒2型感染的流行率和发病率估计数。
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