补充脱氢表雄酮对卵巢储备功能减退小鼠的影响。
Effects of dehydroepiandrosterone supplementation on mice with diminished ovarian reserve.
作者信息
Lin Xiufeng, Du Jing, Du Yan, Wu Riran, Fang Xiaowu, Liao Yuechan, Quan Song
机构信息
a Reproductive Medical Center, Department of Obstetrics and Gynecology , Nanfang Hospital, Southern Medical University , Guangzhou , China.
b Reproductive Medical Center , Boai Hospital of Zhongshan , Zhongshan , Guangdong Province , China.
出版信息
Gynecol Endocrinol. 2018 Apr;34(4):357-359. doi: 10.1080/09513590.2017.1409712. Epub 2017 Dec 8.
Dehydroepiandrosterone (DHEA) has been used to improve the pregnancy rate in women with diminished ovarian reserve(DOR) during in vitro fertilization. We aimed to validate the effects of DHEA and identify the possible mechanisms. We constructed a mice model with DOR and analyzed the hormone parameters and follicle counts. In vivo experiment, FSH and LH concentrations in the serum were significantly elevated in the DOR group. However, the FSH and LH concentrations were partially reversed in the DOR + DHEA group. The E2, AMH and INHB were down-regulated in the DOR group and reversed in the DOR + DHEA group. Our study supported evidences that DHEA might modulate the hormone receptors in the ovary and hormone secretions to the peripheral circulation to regulate the ovary reserve functions.
脱氢表雄酮（DHEA）已被用于提高体外受精期间卵巢储备功能减退（DOR）女性的妊娠率。我们旨在验证DHEA的作用并确定可能的机制。我们构建了DOR小鼠模型并分析了激素参数和卵泡计数。在体内实验中，DOR组血清中的FSH和LH浓度显著升高。然而，DOR + DHEA组的FSH和LH浓度部分逆转。DOR组中E2、AMH和INHB下调，而在DOR + DHEA组中逆转。我们的研究支持了DHEA可能调节卵巢中的激素受体以及向外周循环的激素分泌以调节卵巢储备功能的证据。
Zotero 插件