Dental Industry Department, Al-Noor University College, Ministry of Higher Education and Scientific Research, Mosul, Iraq.
Department of Applied Chemistry, College of Applied Sciences-Hit, University Of Anbar, Ministry of Higher Education and Scientific Research, Anbar, Hit, Iraq.
Steroids. 2024 Nov;211:109490. doi: 10.1016/j.steroids.2024.109490. Epub 2024 Aug 13.
The therapeutic role of dehydroepiandrosterone (DHEA) supplementation among infertile women with diminished ovarian reserve (DOR) is still unclear. Objective evaluation of different ovarian reserve tests (ORTs) such as serum anti-Mullerian hormone (AMH), serum follicle stimulating hormone (FSH), and antral follicle count (AFC) in women with diminished ovarian reserve is required. This is a cross-sectional study performed in Mosul city, Iraq, with 122 infertile women who had been diagnosed with DOR. The enrolled women's age ranged from 18 to 45 years old (mean age of 29.46 ± 2.64 years). The ages of the enrolled women ranged from 18 to 45 years (mean age of 29.46 ± 2.64 years). To assess the influence of DHEA supplements (25 mg, three times/day for 12 weeks) across different age groups, the women were initially divided into three groups (18 to 27 years old, 28 to 37 years old, and ≥ 38 years old). Significant differences were noticed in AMH, FSH, level and AFC before and after DHEA supplementation. (AMH: 0.64 ± 0.82 vs. 1.98 ± 1.32, AFC: 2.86 ± 0.64 vs. 5.82 ± 2.42, and FSH: 12.44 ± 3.85 vs. 8.12 ± 4.64), statistically obvious significant differences regarding the results of AMH (p < 0.001), AFC (p < 0.001), and FSH (p < 0.001). DHEA supplementations improved the ovarian reserve of the enrolled women, which was more evident in younger women (<38 years old) than older women (≥38 years old). The AMH serum levels and AFC value can be considered the best, most reliable and significant OR parameters. However, large randomized multicenter studies are required to confirm the available results and data.
脱氢表雄酮 (DHEA) 补充剂在卵巢储备功能降低 (DOR) 的不孕女性中的治疗作用尚不清楚。需要对卵巢储备功能降低的女性进行不同的卵巢储备测试 (ORT) 的客观评估，例如血清抗苗勒管激素 (AMH)、血清卵泡刺激素 (FSH) 和窦卵泡计数 (AFC)。这是在伊拉克摩苏尔市进行的一项横断面研究，共纳入 122 例被诊断为 DOR 的不孕女性。纳入女性的年龄为 18 至 45 岁（平均年龄 29.46 ± 2.64 岁）。纳入女性的年龄为 18 至 45 岁（平均年龄 29.46 ± 2.64 岁）。为了评估 DHEA 补充剂（25mg，每日 3 次，共 12 周）在不同年龄组中的影响，女性最初分为三组（18 至 27 岁、28 至 37 岁和≥38 岁）。在 DHEA 补充前后，AMH、FSH 水平和 AFC 均有显著差异。（AMH：0.64 ± 0.82 对 1.98 ± 1.32，AFC：2.86 ± 0.64 对 5.82 ± 2.42，FSH：12.44 ± 3.85 对 8.12 ± 4.64），AMH（p<0.001）、AFC（p<0.001）和 FSH（p<0.001）结果具有统计学显著差异。DHEA 补充改善了纳入女性的卵巢储备功能，在年龄较小的女性（<38 岁）中比年龄较大的女性（≥38 岁）更为明显。血清 AMH 水平和 AFC 值可被视为最佳、最可靠和最重要的 OR 参数。然而，需要进行大型随机多中心研究来证实现有结果和数据。
