Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.
Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Kwai Chung, Hong Kong.
J Assist Reprod Genet. 2018 May;35(5):857-862. doi: 10.1007/s10815-018-1152-2. Epub 2018 Mar 9.
To evaluate the effect of 12-month DHEA supplementation on menstrual pattern and ovarian reserve markers in women with premature ovarian insufficiency (POI) METHODS: This is a prospective observational study. Women with POI were given DHEA supplements (25 mg three times daily) for 12 months. Sonographic assessment for ovarian volume and antral follicle count (AFC) and serum measurement for anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), estradiol, testosterone, liver function, and hemoglobin level were performed at baseline and monthly for 13 months after the supplementation. Menstrual pattern, ovarian reserve markers, and side-effects were recorded.
Between August 2011 and July 2014, 38 women with POI were recruited and 31 completed the study. The median age of women was 36 years, and the median baseline FSH and AMH concentrations were 82.2 IU/L and 0.01 ng/ml, respectively. No women had resumption of regular menstruation after DHEA supplementation. AMH, FSH, and AFC did not change significantly. No serious side effects were reported.
Our results do not support any significant improvement in ovarian function by 12-month DHEA supplementation in women with POI.
评估 12 个月脱氢表雄酮（DHEA）补充对卵巢早衰（POI）女性月经模式和卵巢储备标志物的影响。
这是一项前瞻性观察性研究。POI 女性接受 DHEA 补充剂（25mg，每日 3 次）治疗 12 个月。在基线时和补充后 13 个月每月进行超声评估卵巢体积和窦卵泡计数（AFC），以及血清抗苗勒管激素（AMH）、卵泡刺激素（FSH）、雌二醇、睾酮、肝功能和血红蛋白水平检测。记录月经模式、卵巢储备标志物和副作用。
2011 年 8 月至 2014 年 7 月期间，招募了 38 名 POI 女性，其中 31 名完成了研究。女性的中位年龄为 36 岁，中位基线 FSH 和 AMH 浓度分别为 82.2IU/L 和 0.01ng/ml。DHEA 补充后没有女性恢复规律月经。AMH、FSH 和 AFC 没有显著变化。未报告严重副作用。
我们的结果不支持 12 个月 DHEA 补充对 POI 女性卵巢功能有任何显著改善。
